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Gene Review:

bmp7a - bone morphogenetic protein 7a

Danio rerio

Synonyms: SO:0000704, bmp7, fb83f09, wu:fb83f09

Schmid, B. et al., Nguyen, V.H. et al., Kramer, C. et al., Jasuja, R. et al.

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High impact information on bmp7

Double mutant snailhouse/bmp7; swirl/bmp2b embryos do not exhibit additional or stronger dorsalized phenotypes, indicating that these Bmp ligands do not function redundantly in early embryonic development [1].
From the relative efficiencies observed in Bmp ligand rescue experiments, conserved chromosomal synteny, and isolation of the zebrafish bmp7 gene, we determined that the strongly dorsalized snailhouse mutant phenotype is caused by a mutation in the bmp7 gene [1].
A similar early role for Bmp signaling is suggested in the specification of dorsal neural cell types, since the bmp2b/swirl and bmp7/snailhouse genes are only coexpressed during gastrulation and within the tail bud, and are not found in the dorsal neural tube or overlying epidermal ectoderm [2].
Embryos lacking maternal Smad5 function (Mm169(-/-) embryos) are even more strongly dorsalized thanbmp2b or bmp7 null mutants [3].
Most importantly, Mm169(-/-) embryos display reducedbmp7 mRNA levels during blastula stages, when bmp2b and bmp7 mutants are still normal [3].

Biological context of bmp7

However, simultaneous knockdown of mini fin and bmp1 results in severe dorsalization resembling the Swirl (swr) and Snailhouse (snh) phenotypes; caused by defects in major zebrafish ventralizing genes bmp2b and bmp7, respectively [4].

References

Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation. Schmid, B., Fürthauer, M., Connors, S.A., Trout, J., Thisse, B., Thisse, C., Mullins, M.C. Development (2000) [Pubmed]
Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway. Nguyen, V.H., Trout, J., Connors, S.A., Andermann, P., Weinberg, E., Mullins, M.C. Development (2000) [Pubmed]
Maternally supplied Smad5 is required for ventral specification in zebrafish embryos prior to zygotic Bmp signaling. Kramer, C., Mayr, T., Nowak, M., Schumacher, J., Runke, G., Bauer, H., Wagner, D.S., Schmid, B., Imai, Y., Talbot, W.S., Mullins, M.C., Hammerschmidt, M. Dev. Biol. (2002) [Pubmed]
bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis. Jasuja, R., Voss, N., Ge, G., Hoffman, G.G., Lyman-Gingerich, J., Pelegri, F., Greenspan, D.S. Mech. Dev. (2006) [Pubmed]

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