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Gene Review

TOMM40  -  translocase of outer mitochondrial...

Homo sapiens

Synonyms: C19orf1, D19S1177E, Mitochondrial import receptor subunit TOM40 homolog, PER-EC1, PEREC1, ...
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Disease relevance of TOMM40


High impact information on TOMM40


Biological context of TOMM40


Anatomical context of TOMM40

  • Rather, two major components from the TOM (translocase of the outer mitochondrial membrane) complex, namely TOM20 and TOM40, are important for tRNA binding at the surface of mitochondria, suggesting that they are also involved in tRNA import [6].
  • Semiquantitative studies revealed a greater level of p38.5 gene transcription in malignant cell lines compared with nonmalignant cells [4].
  • The mitochondrial Tom40, Tim23 and adenine nucleotide transporter (ANT) contents were not significantly different between non-preconditioned and preconditioned myocardium [7].
  • Blue native polyacrylamide gel electrophoresis of digitonin-solubilized outer membranes revealed that 1C9-2 is firmly associated with TOM40 in the approximately 400-kDa complex, with a size and composition similar to those of the fungal TOM core complex [8].
  • Insertion of VDAC into the outer membrane is unaffected by plugging the translocation pore with a partially translocated matrix preprotein, and mitochondria containing a temperature-sensitive mutant of Tom40 insert VDAC at the nonpermissive temperature [9].

Associations of TOMM40 with chemical compounds


Other interactions of TOMM40


Analytical, diagnostic and therapeutic context of TOMM40

  • Anti-p38.5 antibody against the 11-mer peptide encoded in exon 5 and against a 25-mer peptide encoded in exon 1 both reacted with the same protein in immunoprecipitation studies, providing further evidence of identity [4].
  • Genetic identity and differential expression of p38.5 (Haymaker) in human malignant and nonmalignant cells [4].
  • Dissection of the mitochondrial import and assembly pathway for human Tom40 [12].
  • Significant differences in Haymaker expression, as assessed by immunohistochemistry, between malignant and normal gynecologic tissues were not observed (p = 0.27) [1].


  1. Haymaker gene expression in malignant and normal gynecologic tissues. Borowsky, M.E., Das, B., Axiotis, C.A., Malka, E.S., Abulafia, O., Norin, A.J. J. Histochem. Cytochem. (2006) [Pubmed]
  2. Preferential interaction of a novel tumor surface protein (p38.5) with naive natural killer cells. Das, B., Mondragon, M.O., Tao, S.Z., Norin, A.J. J. Exp. Med. (1997) [Pubmed]
  3. Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10. Meisinger, C., Wiedemann, N., Rissler, M., Strub, A., Milenkovic, D., Schönfisch, B., Müller, H., Kozjak, V., Pfanner, N. J. Biol. Chem. (2006) [Pubmed]
  4. Genetic identity and differential expression of p38.5 (Haymaker) in human malignant and nonmalignant cells. Das, B., Tao, S.Z., Mushnitsky, R., Norin, A.J. Int. J. Cancer (2001) [Pubmed]
  5. Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1. Freitas, E.M., Zhang, W.J., Lalonde, J.P., Tay, G.K., Gaudieri, S., Ashworth, L.K., Van Bockxmeer, F.M., Dawkins, R.L. DNA Seq. (1998) [Pubmed]
  6. The voltage-dependent anion channel, a major component of the tRNA import machinery in plant mitochondria. Salinas, T., Duch??ne, A.M., Delage, L., Nilsson, S., Glaser, E., Zaepfel, M., Mar??chal-Drouard, L. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. Prevention of the ischemia-induced decrease in mitochondrial Tom20 content by ischemic preconditioning. Boengler, K., Gres, P., Cabestrero, A., Ruiz-Meana, M., Garcia-Dorado, D., Heusch, G., Schulz, R. J. Mol. Cell. Cardiol. (2006) [Pubmed]
  8. Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane. Saeki, K., Suzuki, H., Tsuneoka, M., Maeda, M., Iwamoto, R., Hasuwa, H., Shida, S., Takahashi, T., Sakaguchi, M., Endo, T., Miura, Y., Mekada, E., Mihara, K. J. Biol. Chem. (2000) [Pubmed]
  9. Direct membrane insertion of voltage-dependent anion-selective channel protein catalyzed by mitochondrial Tom20. Schleiff, E., Silvius, J.R., Shore, G.C. J. Cell Biol. (1999) [Pubmed]
  10. Phenotype-based identification of host genes required for replication of African swine fever virus. Chang, A.C., Zsak, L., Feng, Y., Mosseri, R., Lu, Q., Kowalski, P., Zsak, A., Burrage, T.G., Neilan, J.G., Kutish, G.F., Lu, Z., Laegreid, W., Rock, D.L., Cohen, S.N. J. Virol. (2006) [Pubmed]
  11. Characterization of the preprotein translocase of the outer mitochondrial membrane by blue native electrophoresis. Dekker, P.J., Müller, H., Rassow, J., Pfanner, N. Biol. Chem. (1996) [Pubmed]
  12. Dissection of the mitochondrial import and assembly pathway for human Tom40. Humphries, A.D., Streimann, I.C., Stojanovski, D., Johnston, A.J., Yano, M., Hoogenraad, N.J., Ryan, M.T. J. Biol. Chem. (2005) [Pubmed]
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