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Gene Review

EHD3  -  EH-domain containing 3

Homo sapiens

Synonyms: EH domain-containing protein 3, EHD2, PAST homolog 3, PAST3
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High impact information on EHD3

  • The results presented herein promote a coordinated role for EHD proteins and Rab11-FIP2 in mediating endocytic recycling and provide evidence for the function of EHD3 in early endosome to ERC transport [1].
  • Moreover, the subcellular localization of Rab11-FIP2 and endogenous Rab11 were altered upon EHD3 knockdown, with both proteins absent from the ERC and retained in the cell periphery [1].
  • Based on its specific intracellular localization and its interaction with EHD1, we postulate that EHD3 localizes on endocytic tubular and vesicular structures and regulates their microtubule-dependent movement [2].
  • EHD3, expressed as a green fluorescent fusion protein was localized to endocytic vesicles and to microtubule-dependent, membrane tubules [2].
  • Knock-down analyses indicated that EHD1 and 2 regulate the exit of cargo from the recycling endosome while EHD4, similar to that reported for EHD3 (Naslavsky et al. (2006) Mol. Biol. Cell 17, 163), regulates transport from the early endosome to the recycling endosome [3].


  1. Interactions between EHD proteins and Rab11-FIP2: a role for EHD3 in early endosomal transport. Naslavsky, N., Rahajeng, J., Sharma, M., Jovic, M., Caplan, S. Mol. Biol. Cell (2006) [Pubmed]
  2. EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1. Galperin, E., Benjamin, S., Rapaport, D., Rotem-Yehudar, R., Tolchinsky, S., Horowitz, M. Traffic (2002) [Pubmed]
  3. Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans. George, M., Ying, G., Rainey, M.A., Solomon, A., Parikh, P.T., Gao, Q., Band, V., Band, H. BMC Cell Biol. (2007) [Pubmed]
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