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Gene Review

RAB11A  -  RAB11A, member RAS oncogene family

Homo sapiens

Synonyms: RAB11, Rab-11, Ras-related protein Rab-11A, YL8
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Disease relevance of RAB11A


High impact information on RAB11A

  • The three GTPases Rab5, Rab4 and Rab11 regulate sequential transport steps along the endocytic/recycling pathway, and occupy distinct membrane domains on early and recycling endosomes [4].
  • Localization of MT1-MMP within VSV-G/Rab8-positive vesicles, but not in Rab11/Tf/TfRc-positive compartment in invasive cells, suggests the involvement of the exocytic traffic pathway [5].
  • Hence, we propose that FIP3 and FIP4 serve to couple Rab11-positive vesicle traffic from recycling endosomes to the cleavage furrow/midbody where they are tethered prior to fusion events via interactions with Arf6 and the Exocyst [6].
  • The second was EEA-1 negative and with time recruited Rab11, suggesting that cytoplasts assembled functional REs [7].
  • Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11 [8].

Biological context of RAB11A


Anatomical context of RAB11A


Associations of RAB11A with chemical compounds


Physical interactions of RAB11A

  • The Rab11 family of interacting proteins (Rab11-FIP) is a recently identified protein family composed of, to date, six members that interact with Rab11 [13].
  • Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells [14].
  • Myosin Vb interacts with Rab11 family members and is the major motor protein identified in association with plasma membrane recycling systems in nonpolarized and polarized cells [18].
  • Molecular dissection of Rab11 binding from coiled-coil formation in the Rab11-FIP2 C-terminal domain [19].
  • Expression of a rab11 mutant deficient in GTP binding (as a fusion between enhanced green fluorescent protein (EGFP) and the rab11S25N mutant) significantly slowed receptor recycling to the cell surface from dispersed transferrin-positive peripheral vesicles following a brief exposure to agonist [11].

Co-localisations of RAB11A


Regulatory relationships of RAB11A


Other interactions of RAB11A

  • We have identified a novel 80-kDa protein that interacts specifically with the GTP-bound conformation of Rab4, and subsequent work has shown that it also interacts strongly with Rab11 [23].
  • The isolated clone, corresponding to the carboxyl terminal 60 kDa of the myosin Vb tail, interacted with all members of the Rab11 family (Rab11a, Rab11b, and Rab25) [24].
  • Rather, Gaf-1/Rip11 was capable of serving a link between gamma-SNAP and Rab11 [25].
  • It colocalizes with early endosomal markers including Rab4 and Rab11 as well as with the transferrin receptor [23].
  • Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout [26].

Analytical, diagnostic and therapeutic context of RAB11A


  1. Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia. Ray, G.S., Lee, J.R., Nwokeji, K., Mills, L.R., Goldenring, J.R. Lab. Invest. (1997) [Pubmed]
  2. Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin. Yoon, S.O., Shin, S., Mercurio, A.M. Cancer Res. (2005) [Pubmed]
  3. Ganglioside GD3 traffics from the trans-Golgi network to plasma membrane by a Rab11-independent and brefeldin A-insensitive exocytic pathway. Crespo, P.M., Iglesias-Bartolomé, R., Daniotti, J.L. J. Biol. Chem. (2004) [Pubmed]
  4. Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes. de Renzis, S., Sönnichsen, B., Zerial, M. Nat. Cell Biol. (2002) [Pubmed]
  5. MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway. Bravo-Cordero, J.J., Marrero-Diaz, R., Megías, D., Genís, L., García-Grande, A., García, M.A., Arroyo, A.G., Montoya, M.C. EMBO J. (2007) [Pubmed]
  6. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. Fielding, A.B., Schonteich, E., Matheson, J., Wilson, G., Yu, X., Hickson, G.R., Srivastava, S., Baldwin, S.A., Prekeris, R., Gould, G.W. EMBO J. (2005) [Pubmed]
  7. Transferrin receptor recycling in the absence of perinuclear recycling endosomes. Sheff, D., Pelletier, L., O'Connell, C.B., Warren, G., Mellman, I. J. Cell Biol. (2002) [Pubmed]
  8. Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11. Sönnichsen, B., De Renzis, S., Nielsen, E., Rietdorf, J., Zerial, M. J. Cell Biol. (2000) [Pubmed]
  9. The RCP-Rab11 complex regulates endocytic protein sorting. Peden, A.A., Schonteich, E., Chun, J., Junutula, J.R., Scheller, R.H., Prekeris, R. Mol. Biol. Cell (2004) [Pubmed]
  10. Identification of a putative effector protein for rab11 that participates in transferrin recycling. Zeng, J., Ren, M., Gravotta, D., De Lemos-Chiarandini, C., Lui, M., Erdjument-Bromage, H., Tempst, P., Xu, G., Shen, T.H., Morimoto, T., Adesnik, M., Sabatini, D.D. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  11. Rab11 regulates the recycling and lysosome targeting of beta2-adrenergic receptors. Moore, R.H., Millman, E.E., Alpizar-Foster, E., Dai, W., Knoll, B.J. J. Cell. Sci. (2004) [Pubmed]
  12. Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3. Drivas, G.T., Shih, A., Coutavas, E.E., D'Eustachio, P., Rush, M.G. Oncogene (1991) [Pubmed]
  13. The C2 domains of the class I Rab11 family of interacting proteins target recycling vesicles to the plasma membrane. Lindsay, A.J., McCaffrey, M.W. J. Cell. Sci. (2004) [Pubmed]
  14. Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. Wallace, D.M., Lindsay, A.J., Hendrick, A.G., McCaffrey, M.W. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  15. Rab11BP/Rabphilin-11, a downstream target of rab11 small G protein implicated in vesicle recycling. Mammoto, A., Ohtsuka, T., Hotta, I., Sasaki, T., Takai, Y. J. Biol. Chem. (1999) [Pubmed]
  16. Endogenous plasma membrane t-SNARE syntaxin 4 is present in rab11 positive endosomal membranes and associates with cortical actin cytoskeleton. Band, A.M., Ali, H., Vartiainen, M.K., Welti, S., Lappalainen, P., Olkkonen, V.M., Kuismanen, E. FEBS Lett. (2002) [Pubmed]
  17. Modulation of cellular cholesterol transport and homeostasis by Rab11. Hölttä-Vuori, M., Tanhuanpää, K., Möbius, W., Somerharju, P., Ikonen, E. Mol. Biol. Cell (2002) [Pubmed]
  18. Interactions of myosin vb with rab11 family members and cargoes traversing the plasma membrane recycling system. Lapierre, L.A., Goldenring, J.R. Meth. Enzymol. (2005) [Pubmed]
  19. Molecular dissection of Rab11 binding from coiled-coil formation in the Rab11-FIP2 C-terminal domain. Wei, J., Fain, S., Harrison, C., Feig, L.A., Baleja, J.D. Biochemistry (2006) [Pubmed]
  20. Interaction of the Salmonella-containing vacuole with the endocytic recycling system. Smith, A.C., Cirulis, J.T., Casanova, J.E., Scidmore, M.A., Brumell, J.H. J. Biol. Chem. (2005) [Pubmed]
  21. Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin. Lock, J.G., Stow, J.L. Mol. Biol. Cell (2005) [Pubmed]
  22. Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes. Ren, M., Xu, G., Zeng, J., De Lemos-Chiarandini, C., Adesnik, M., Sabatini, D.D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  23. Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. Lindsay, A.J., Hendrick, A.G., Cantalupo, G., Senic-Matuglia, F., Goud, B., Bucci, C., McCaffrey, M.W. J. Biol. Chem. (2002) [Pubmed]
  24. Myosin vb is associated with plasma membrane recycling systems. Lapierre, L.A., Kumar, R., Hales, C.M., Navarre, J., Bhartur, S.G., Burnette, J.O., Provance, D.W., Mercer, J.A., Bähler, M., Goldenring, J.R. Mol. Biol. Cell (2001) [Pubmed]
  25. Mapping of functional domains of gamma-SNAP. Tani, K., Shibata, M., Kawase, K., Kawashima, H., Hatsuzawa, K., Nagahama, M., Tagaya, M. J. Biol. Chem. (2003) [Pubmed]
  26. Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout. Hickson, G.R., Matheson, J., Riggs, B., Maier, V.H., Fielding, A.B., Prekeris, R., Sullivan, W., Barr, F.A., Gould, G.W. Mol. Biol. Cell (2003) [Pubmed]
  27. Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins. Junutula, J.R., Schonteich, E., Wilson, G.M., Peden, A.A., Scheller, R.H., Prekeris, R. J. Biol. Chem. (2004) [Pubmed]
  28. The intracellular trafficking of the G protein-coupled receptor TPbeta depends on a direct interaction with Rab11. Hamelin, E., Thériault, C., Laroche, G., Parent, J.L. J. Biol. Chem. (2005) [Pubmed]
  29. Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis. Horgan, C.P., Walsh, M., Zurawski, T.H., McCaffrey, M.W. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  30. Molecular cloning and characterization of a ras p21-like GTP-binding protein (24KG) from rat liver. Sakurada, K., Uchida, K., Yamaguchi, K., Aisaka, K., Ito, S., Ohmori, T., Takeyama, Y., Ueda, T., Hori, Y., Ohyanagi, H. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
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