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Gene Review

EHD1  -  EH-domain containing 1

Homo sapiens

Synonyms: CDABP0131, EH domain-containing protein 1, FLJ42622, FLJ44618, H-PAST, ...
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Disease relevance of EHD1

  • At day 15.5 EHD1 expression peaked in cartilage, preceding hypertrophy and ossification, and at day 17.5 there was no expression in the bones [1].
  • Pasteurella canis was the most common isolate of dog bites, and Past. multocida subspecies multocida and septica were the most common isolates of cat bites [2].
  • Brucellosis in the United States. Past, present, and future [3].
  • Caring for the Critically Ill Patient: Past, present, and future [4].
  • CONCLUSIONS: Past treatments with alkylating agents and radiation therapy for Hodgkin's disease were associated with an increased risk of lung cancer in a dose-dependent and additive fashion [5].

Psychiatry related information on EHD1

  • Depression was measured by using the Beck Depression Inventory, the Hamilton Rating Scale for Depression, and the Current and Past Psychopathology Scales [6].
  • RESULTS: Past substance abuse was evident in 34% of the bipolar sample and comprised most often alcoholism (82%), followed by cocaine (30%), marijuana (29%), sedative-hypnotic or amphetamine (21%), and opiate (13%) abuse [7].
  • INTERPRETATION: Past exposure to vaccines against diphtheria or tetanus, poliomyelitis and influenza may protect against subsequent development of Alzheimer's disease [8].
  • OBJECTIVE: Past research has demonstrated that self-disclosure of traumatic or secretive information produces observable health benefits [9].
  • OBJECTIVE: Past research and experience have indicated that characteristics of organizations and service systems influence the quality of mental health services delivery [10].

High impact information on EHD1


Chemical compound and disease context of EHD1

  • Factor analysis revealed 6 theoretically meaningful factors: Environmental Influences, Loss of Control, Health Care Avoidance, Past and Current Experience, Physiological Responsivity, and Thoughts of Disease Progression [16].
  • In the past 1 1/2 years we have encountered three unusual cases involving individuals who were treated with large doses of metronidazole for Crohn's disease and who developed a malignant neoplasm at a relatively young age [17].
  • BACKGROUND: Past studies have suggested that treatment outcomes can be improved if a triptan is administered early in the time course of a migraine attack [18].
  • METHODS: Fifty-six tamoxifen-related endometrial cancers were identified from 10 hospitals in Japan. Past users were defined as endometrial cancer patients diagnosed more than 12 months after the cessation of tamoxifen treatment for breast cancer [19].
  • BACKGROUND: Past studies have reported a correlation between the presence and severity of periodontitis and serum antibody titers to species-specific antigens of Porphyromonas gingivalis or to cross-reactive antigens, such as lipopolysaccharide (LPS) and heat shock proteins (HSP), shared between P. gingivalis and other bacteria [20].

Biological context of EHD1

  • The three EHD1 paralogs therefore represent novel members of a family of human EH domain-containing proteins that may play a role in endocytosis and signaling [21].
  • A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane [22].
  • To address the functional roles of EHD1 and Rabenosyn-5, we first demonstrated that RNA interference (RNAi) dramatically reduced the level of expression of each protein, either individually or in combination [23].
  • Simultaneous RNAi depletion of both proteins resulted in a similar phenotype to that observed with Rabenosyn-5-RNAi alone, suggesting that Rabenosyn-5 acts before EHD1 in the regulation of endocytic recycling [23].
  • Immunostaining of different adult mouse organs revealed major expression of EHD1 in germ cells in meiosis, in the testes, in adipocytes, and in specific retinal layers [1].

Anatomical context of EHD1

  • Similarly, small interfering RNA-mediated depletion of endogenous EHD1 protein also markedly dispersed perinuclear GLUT4 in cultured adipocytes [24].
  • RNA analysis of many tissues revealed that expression of EHD1 is ubiquitous, with elevated levels in the testis [25].
  • EHD1 and EHD4 control recycling by regulating the transport of receptors from the recycling compartment to the plasma membrane [26].
  • Knock-down analyses indicated that EHD1 and 2 regulate the exit of cargo from the recycling endosome while EHD4, similar to that reported for EHD3 (Naslavsky et al. (2006) Mol. Biol. Cell 17, 163), regulates transport from the early endosome to the recycling endosome [27].
  • EHD1 appears to induce tubule formation, which requires nucleotide cycling on Arf6 and intact microtubules [22].

Associations of EHD1 with chemical compounds


Physical interactions of EHD1


Regulatory relationships of EHD1

  • These observations suggest an additional function of EHD1 as a tubule-inducing factor in the Arf6 pathway for recycling of plasma membrane proteins internalized by clathrin-independent endocytosis [22].

Other interactions of EHD1

  • Evaluation and molecular characterization of EHD1, a candidate gene for Bardet-Biedl syndrome 1 (BBS1) [25].
  • EH domain deletion mutants of EHD1 and 3 but not 2 or 4, induced a striking perinuclear clustering of co-transfected Rab11 [27].
  • Here, we report that endogenous EHD proteins, as well as transgenic tagged EHD1, are associated with long, membrane-bound tubules containing Arf6 [22].
  • These results are consistent with a coordinated role for EHD1 and Rab11-FIP2 in regulating exit from the ERC [33].
  • Surprisingly, loss of EHD3 expression prevented the delivery of internalized transferrin and early endosomal proteins to the ERC, an effect differing from that described upon EHD1 knockdown [33].

Analytical, diagnostic and therapeutic context of EHD1

  • Immunofluorescence microscopy studies revealed that EHD1 and Rabenosyn-5 partially colocalize to vesicular and tubular structures in vivo [23].
  • Co-immunoprecipitation suggests that GS32 could also interact with EHD1 in intact cells [34] .
  • PURPOSE: Past reports and meta-analyses indicate that fluoroquinolones are highly effective in preventing Gram-negative infections in neutropenic cancer patients, but offer inadequate coverage for Gram-positive infections [35].
  • SUMMARY BACKGROUND DATA: Past studies have identified a significant volume-outcome relation for hospitals performing pancreaticoduodenectomy (the Whipple procedure) [36].


  1. EHD1--an EH-domain-containing protein with a specific expression pattern. Mintz, L., Galperin, E., Pasmanik-Chor, M., Tulzinsky, S., Bromberg, Y., Kozak, C.A., Joyner, A., Fein, A., Horowitz, M. Genomics (1999) [Pubmed]
  2. Bacteriologic analysis of infected dog and cat bites. Emergency Medicine Animal Bite Infection Study Group. Talan, D.A., Citron, D.M., Abrahamian, F.M., Moran, G.J., Goldstein, E.J. N. Engl. J. Med. (1999) [Pubmed]
  3. Brucellosis in the United States. Past, present, and future. Wise, R.I. JAMA (1980) [Pubmed]
  4. Caring for the Critically Ill Patient: Past, present, and future. Cook, D.J. JAMA (1998) [Pubmed]
  5. Lung cancer following chemotherapy and radiotherapy for Hodgkin's disease. Travis, L.B., Gospodarowicz, M., Curtis, R.E., Clarke, E.A., Andersson, M., Glimelius, B., Joensuu, T., Lynch, C.F., van Leeuwen, F.E., Holowaty, E., Storm, H., Glimelius, I., Pukkala, E., Stovall, M., Fraumeni, J.F., Boice, J.D., Gilbert, E. J. Natl. Cancer Inst. (2002) [Pubmed]
  6. Depression, demographic dimensions, and drug abuse. Dorus, W., Senay, E.C. The American journal of psychiatry. (1980) [Pubmed]
  7. A history of substance abuse complicates remission from acute mania in bipolar disorder. Goldberg, J.F., Garno, J.L., Leon, A.C., Kocsis, J.H., Portera, L. The Journal of clinical psychiatry. (1999) [Pubmed]
  8. Past exposure to vaccines and subsequent risk of Alzheimer's disease. Verreault, R., Laurin, D., Lindsay, J., De Serres, G. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. (2001) [Pubmed]
  9. When children tell their friends they have AIDS: possible consequences for psychological well-being and disease progression. Sherman, B.F., Bonanno, G.A., Wiener, L.S., Battles, H.B. Psychosomatic medicine. (2000) [Pubmed]
  10. Relations between program and system variables and fidelity to the wraparound process for children and families. Bruns, E.J., Suter, J.C., Leverentz-Brady, K.M. Psychiatric services (Washington, D.C.) (2006) [Pubmed]
  11. Bone mineral density in women with depression. Michelson, D., Stratakis, C., Hill, L., Reynolds, J., Galliven, E., Chrousos, G., Gold, P. N. Engl. J. Med. (1996) [Pubmed]
  12. The radiation effects research foundation of Hiroshima and Nagasaki. Past, present, and future. Shigematsu, I., Mendelsohn, M.L. JAMA (1995) [Pubmed]
  13. Lithium treatment of manic-depressive illness. Past, present, and perspectives. Schou, M. JAMA (1988) [Pubmed]
  14. Treatment-associated leukemia following testicular cancer. Travis, L.B., Andersson, M., Gospodarowicz, M., van Leeuwen, F.E., Bergfeldt, K., Lynch, C.F., Curtis, R.E., Kohler, B.A., Wiklund, T., Storm, H., Holowaty, E., Hall, P., Pukkala, E., Sleijfer, D.T., Clarke, E.A., Boice, J.D., Stovall, M., Gilbert, E. J. Natl. Cancer Inst. (2000) [Pubmed]
  15. Colonoscopic screening of persons with suspected risk factors for colon cancer: II. Past history of colorectal neoplasms. Grossman, S., Milos, M.L., Tekawa, I.S., Jewell, N.P. Gastroenterology (1989) [Pubmed]
  16. Biobehavioral pain profile: development and psychometric properties. Dalton, J.A., Feuerstein, M., Carlson, J., Roghman, K. Pain (1994) [Pubmed]
  17. Occurrence of three cases of carcinoma in individuals with Crohn's disease treated with metronidazole. Krause, J.R., Ayuyang, H.Q., Ellis, L.D. Am. J. Gastroenterol. (1985) [Pubmed]
  18. Efficacy of Rizatriptan 10 mg administered early in a migraine attack. Cady, R., Martin, V., Mauskop, A., Rodgers, A., Hustad, C.M., Ramsey, K.E., Skobieranda, F. Headache. (2006) [Pubmed]
  19. Clinicopathologic study of 56 patients with endometrial cancer during or after adjuvant tamoxifen use for their breast cancers. Hachisuga, T., Saito, T., Kigawa, J., Ohwada, M., Yamazawa, K., Yasue, A., Iwasaka, T., Sugiyama, T., Kita, T., Nagai, N. Gynecol. Oncol. (2004) [Pubmed]
  20. Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis. Sims, T.J., Lernmark, A., Mancl, L.A., Schifferle, R.E., Page, R.C., Persson, G.R. Journal of clinical periodontology. (2002) [Pubmed]
  21. EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins. Pohl, U., Smith, J.S., Tachibana, I., Ueki, K., Lee, H.K., Ramaswamy, S., Wu, Q., Mohrenweiser, H.W., Jenkins, R.B., Louis, D.N. Genomics (2000) [Pubmed]
  22. A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane. Caplan, S., Naslavsky, N., Hartnell, L.M., Lodge, R., Polishchuk, R.S., Donaldson, J.G., Bonifacino, J.S. EMBO J. (2002) [Pubmed]
  23. Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane. Naslavsky, N., Boehm, M., Backlund, P.S., Caplan, S. Mol. Biol. Cell (2004) [Pubmed]
  24. Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes. Guilherme, A., Soriano, N.A., Furcinitti, P.S., Czech, M.P. J. Biol. Chem. (2004) [Pubmed]
  25. Evaluation and molecular characterization of EHD1, a candidate gene for Bardet-Biedl syndrome 1 (BBS1). Haider, N.B., Searby, C., Galperin, E., Mintz, L., Horowitz, M., Stone, E.M., Sheffield, V.C. Gene (1999) [Pubmed]
  26. C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH? Naslavsky, N., Caplan, S. J. Cell. Sci. (2005) [Pubmed]
  27. Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans. George, M., Ying, G., Rainey, M.A., Solomon, A., Parikh, P.T., Gao, Q., Band, V., Band, H. BMC Cell Biol. (2007) [Pubmed]
  28. A short echo proton magnetic resonance spectroscopy study of the left mesial-temporal lobe in first-onset schizophrenic patients. Bartha, R., al-Semaan, Y.M., Williamson, P.C., Drost, D.J., Malla, A.K., Carr, T.J., Densmore, M., Canaran, G., Neufeld, R.W. Biol. Psychiatry (1999) [Pubmed]
  29. Alteration in kinase activity but not in protein levels of protein kinase B and glycogen synthase kinase-3beta in ventral prefrontal cortex of depressed suicide victims. Karege, F., Perroud, N., Burkhardt, S., Schwald, M., Ballmann, E., La Harpe, R., Malafosse, A. Biol. Psychiatry (2007) [Pubmed]
  30. New antiepileptic drugs: review on drug interactions. Hachad, H., Ragueneau-Majlessi, I., Levy, R.H. Therapeutic drug monitoring. (2002) [Pubmed]
  31. The Nobel Lectures in Immunology. The Nobel Prize for Physiology or Medicine, 1980. The major histocompatibility complex in man. Past, present, and future concepts. Dansset, J. Scand. J. Immunol. (1992) [Pubmed]
  32. Platelet monoamine oxidase activity and psychometric correlates in male violent offenders imprisoned for homicide or other violent acts. Skondras, M., Markianos, M., Botsis, A., Bistolaki, E., Christodoulou, G. European archives of psychiatry and clinical neuroscience. (2004) [Pubmed]
  33. Interactions between EHD proteins and Rab11-FIP2: a role for EHD3 in early endosomal transport. Naslavsky, N., Rahajeng, J., Sharma, M., Jovic, M., Caplan, S. Mol. Biol. Cell (2006) [Pubmed]
  34. Mutually exclusive interactions of EHD1 with GS32 and syndapin II. Xu, Y., Shi, H., Wei, S., Wong, S.H., Hong, W. Mol. Membr. Biol. (2004) [Pubmed]
  35. Reappraisal with meta-analysis of the addition of Gram-positive prophylaxis to fluoroquinolone in neutropenic patients. Cruciani, M., Malena, M., Bosco, O., Nardi, S., Serpelloni, G., Mengoli, C. J. Clin. Oncol. (2003) [Pubmed]
  36. Effect of hospital volume and experience on in-hospital mortality for pancreaticoduodenectomy. Ho, V., Heslin, M.J. Ann. Surg. (2003) [Pubmed]
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