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Gene Review

RAB11FIP2  -  RAB11 family interacting protein 2 (class I)

Homo sapiens

Synonyms: KIAA0941, NRip11, Rab11 family-interacting protein 2, Rab11-FIP2, nRip11
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High impact information on RAB11FIP2


Biological context of RAB11FIP2

  • In vitro association assays and co-transfection experiments in both MDCK and HeLa cells confirmed this result but further refined the binding site to amino acids 129-290 of Rab11-FIP2 [3].
  • We also showed that the Rab11-FIP2 coiled-coil domain forms a parallel homodimer in solution using cross-linking and mutagenesis and sedimentation equilibrium experiments [4].
  • Here we show that Rab11-FIP2 may also be involved with the process of receptor-mediated endocytosis [5].

Anatomical context of RAB11FIP2


Associations of RAB11FIP2 with chemical compounds

  • Green fluorescent protein-Rab11-FIP2 (129-512), which lacks its amino-terminal C2 domain, functioned as a dominant negative acting truncation that caused accumulation of Rab11a and disrupted IgA trafficking in MDCK cells and transferrin trafficking in HeLa cells [3].
  • We have found that gastric microsomal membrane extracts phosphorylate Rab11-FIP2 on serine 227 [2].

Physical interactions of RAB11FIP2


Other interactions of RAB11FIP2


Analytical, diagnostic and therapeutic context of RAB11FIP2


  1. Interactions between EHD proteins and Rab11-FIP2: a role for EHD3 in early endosomal transport. Naslavsky, N., Rahajeng, J., Sharma, M., Jovic, M., Caplan, S. Mol. Biol. Cell (2006) [Pubmed]
  2. MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells. Ducharme, N.A., Hales, C.M., Lapierre, L.A., Ham, A.J., Oztan, A., Apodaca, G., Goldenring, J.R. Mol. Biol. Cell (2006) [Pubmed]
  3. Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling. Hales, C.M., Vaerman, J.P., Goldenring, J.R. J. Biol. Chem. (2002) [Pubmed]
  4. Molecular dissection of Rab11 binding from coiled-coil formation in the Rab11-FIP2 C-terminal domain. Wei, J., Fain, S., Harrison, C., Feig, L.A., Baleja, J.D. Biochemistry (2006) [Pubmed]
  5. Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors. Cullis, D.N., Philip, B., Baleja, J.D., Feig, L.A. J. Biol. Chem. (2002) [Pubmed]
  6. Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain. Lindsay, A.J., McCaffrey, M.W. J. Biol. Chem. (2002) [Pubmed]
  7. Identification and characterization of a family of Rab11-interacting proteins. Hales, C.M., Griner, R., Hobdy-Henderson, K.C., Dorn, M.C., Hardy, D., Kumar, R., Navarre, J., Chan, E.K., Lapierre, L.A., Goldenring, J.R. J. Biol. Chem. (2001) [Pubmed]
  8. Interactions of myosin vb with rab11 family members and cargoes traversing the plasma membrane recycling system. Lapierre, L.A., Goldenring, J.R. Meth. Enzymol. (2005) [Pubmed]
  9. Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis. Fan, G.H., Lapierre, L.A., Goldenring, J.R., Sai, J., Richmond, A. Mol. Biol. Cell (2004) [Pubmed]
  10. Purification and functional properties of Rab11-FIP2. Lindsay, A.J., McCaffrey, M.W. Meth. Enzymol. (2005) [Pubmed]
  11. Purification, crystallization and preliminary X-ray diffraction studies of Rab11 in complex with Rab11-FIP2. Jagoe, W.N., Jackson, S.R., Lindsay, A.J., McCaffrey, M.W., Khan, A.R. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
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