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Gene Review:

Sirt1 - sirtuin 1

Rattus norvegicus

Relling, D.P. et al., Cohen, H.Y. et al.

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High impact information on Sirt1_predicted

High-fat diet upregulated the forkhead transcription factor Foxo3a, and suppressed mitochondrial aconitase activity without affecting expression of the caloric sensitive gene silent information regulator 2 (Sir2), protein nitrotyrosine formation, lipid peroxidation and apoptosis [1].

Analytical, diagnostic and therapeutic context of Sirt1_predicted

In yeast, caloric restriction (CR) delays aging by activating the Sir2 deacetylase [2].

References

High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis. Relling, D.P., Esberg, L.B., Fang, C.X., Johnson, W.T., Murphy, E.J., Carlson, E.C., Saari, J.T., Ren, J. J. Hypertens. (2006) [Pubmed]
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Cohen, H.Y., Miller, C., Bitterman, K.J., Wall, N.R., Hekking, B., Kessler, B., Howitz, K.T., Gorospe, M., de Cabo, R., Sinclair, D.A. Science (2004) [Pubmed]

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