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Gene Review

Sirt1  -  sirtuin 1

Mus musculus

Synonyms: AA673258, NAD-dependent protein deacetylase sirtuin-1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, SIR2L1, ...
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Disease relevance of Sirt1


High impact information on Sirt1


Biological context of Sirt1


Anatomical context of Sirt1


Associations of Sirt1 with chemical compounds

  • Pancreatic perfusion experiments further demonstrate that Sirt1 enhances insulin secretion in response to glucose and KCl [9].
  • Treatment with the plant polyphenol resveratrol as well as isonicotinamide, both of which activate Sirt1, blocked adipocyte development and increased the expression of osteoblast markers [10].
  • Furthermore, activation of Sirt1 prevented the increase in adipocytes caused by the PPARgamma-agonist troglitazone [10].
  • Sir2 family deacetylases, which regulate acetyl-coenzyme A synthesis, have recently been shown to impart longevity in a variety of organisms through a pathway related to calorie restriction [11].
  • This type of cell death was blocked by repletion of cellular NAD levels as well as by activation of the longevity factor Sir2alpha deacetylase, indicating that PARP induction and subsequent depletion of NAD levels are the sequence of events causing angiotensin II-mediated cardiomyocyte cell death [12].

Physical interactions of Sirt1

  • Here, we show that mammalian Sir2alpha physically interacts with p53 and attenuates p53-mediated functions [5].

Other interactions of Sirt1

  • These findings suggest that NAD biosynthesis mediated by Nampt regulates the function of Sir2alpha and thereby plays an important role in controlling various biological events in mammals [6].
  • Our findings establish Foxo1 as a direct and functional target for Sir2 in mammalian systems [13].
  • Thus, our findings implicate a p53 regulatory pathway mediated by mammalian Sir2alpha [5].
  • Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain [7].
  • Sir2 is recruited to insulin response sequence-containing promoter and increases the expression of manganese superoxide dismutase and p27(kip1) in a deacetylase-activity-dependent manner [13].


  1. Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Alcendor, R.R., Kirshenbaum, L.A., Imai, S., Vatner, S.F., Sadoshima, J. Circ. Res. (2004) [Pubmed]
  2. Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha. Chen, I.Y., Lypowy, J., Pain, J., Sayed, D., Grinberg, S., Alcendor, R.R., Sadoshima, J., Abdellatif, M. J. Biol. Chem. (2006) [Pubmed]
  3. DNA repair, genome stability, and aging. Lombard, D.B., Chua, K.F., Mostoslavsky, R., Franco, S., Gostissa, M., Alt, F.W. Cell (2005) [Pubmed]
  4. Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Parker, J.A., Arango, M., Abderrahmane, S., Lambert, E., Tourette, C., Catoire, H., Néri, C. Nat. Genet. (2005) [Pubmed]
  5. Negative control of p53 by Sir2alpha promotes cell survival under stress. Luo, J., Nikolaev, A.Y., Imai, S., Chen, D., Su, F., Shiloh, A., Guarente, L., Gu, W. Cell (2001) [Pubmed]
  6. The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. Revollo, J.R., Grimm, A.A., Imai, S. J. Biol. Chem. (2004) [Pubmed]
  7. Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain. Sakamoto, J., Miura, T., Shimamoto, K., Horio, Y. FEBS Lett. (2004) [Pubmed]
  8. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. Bordone, L., Motta, M.C., Picard, F., Robinson, A., Jhala, U.S., Apfeld, J., McDonagh, T., Lemieux, M., McBurney, M., Szilvasi, A., Easlon, E.J., Lin, S.J., Guarente, L. PLoS Biol. (2006) [Pubmed]
  9. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Moynihan, K.A., Grimm, A.A., Plueger, M.M., Bernal-Mizrachi, E., Ford, E., Cras-Méneur, C., Permutt, M.A., Imai, S. Cell metabolism. (2005) [Pubmed]
  10. Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells. Bäckesjö, C.M., Li, Y., Lindgren, U., Haldosén, L.A. J. Bone Miner. Res. (2006) [Pubmed]
  11. Metabolic stress regulates basic transcription through acetyl-coenzyme A. Choi, C.H., Zimon, A., Usheva, A. Cell. Mol. Life Sci. (2005) [Pubmed]
  12. Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy. Pillai, J.B., Gupta, M., Rajamohan, S.B., Lang, R., Raman, J., Gupta, M.P. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  13. Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Daitoku, H., Hatta, M., Matsuzaki, H., Aratani, S., Ohshima, T., Miyagishi, M., Nakajima, T., Fukamizu, A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
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