Gene Review:
Sirt1 - sirtuin 1
Mus musculus
Synonyms:
AA673258, NAD-dependent protein deacetylase sirtuin-1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, SIR2L1, ...
- Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Alcendor, R.R., Kirshenbaum, L.A., Imai, S., Vatner, S.F., Sadoshima, J. Circ. Res. (2004)
- Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha. Chen, I.Y., Lypowy, J., Pain, J., Sayed, D., Grinberg, S., Alcendor, R.R., Sadoshima, J., Abdellatif, M. J. Biol. Chem. (2006)
- DNA repair, genome stability, and aging. Lombard, D.B., Chua, K.F., Mostoslavsky, R., Franco, S., Gostissa, M., Alt, F.W. Cell (2005)
- Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Parker, J.A., Arango, M., Abderrahmane, S., Lambert, E., Tourette, C., Catoire, H., Néri, C. Nat. Genet. (2005)
- Negative control of p53 by Sir2alpha promotes cell survival under stress. Luo, J., Nikolaev, A.Y., Imai, S., Chen, D., Su, F., Shiloh, A., Guarente, L., Gu, W. Cell (2001)
- The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. Revollo, J.R., Grimm, A.A., Imai, S. J. Biol. Chem. (2004)
- Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain. Sakamoto, J., Miura, T., Shimamoto, K., Horio, Y. FEBS Lett. (2004)
- Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. Bordone, L., Motta, M.C., Picard, F., Robinson, A., Jhala, U.S., Apfeld, J., McDonagh, T., Lemieux, M., McBurney, M., Szilvasi, A., Easlon, E.J., Lin, S.J., Guarente, L. PLoS Biol. (2006)
- Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Moynihan, K.A., Grimm, A.A., Plueger, M.M., Bernal-Mizrachi, E., Ford, E., Cras-Méneur, C., Permutt, M.A., Imai, S. Cell metabolism. (2005)
- Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells. Bäckesjö, C.M., Li, Y., Lindgren, U., Haldosén, L.A. J. Bone Miner. Res. (2006)
- Metabolic stress regulates basic transcription through acetyl-coenzyme A. Choi, C.H., Zimon, A., Usheva, A. Cell. Mol. Life Sci. (2005)
- Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy. Pillai, J.B., Gupta, M., Rajamohan, S.B., Lang, R., Raman, J., Gupta, M.P. Am. J. Physiol. Heart Circ. Physiol. (2006)
- Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Daitoku, H., Hatta, M., Matsuzaki, H., Aratani, S., Ohshima, T., Miyagishi, M., Nakajima, T., Fukamizu, A. Proc. Natl. Acad. Sci. U.S.A. (2004)