Gene Review:
Aco2 - aconitase 2, mitochondrial
Rattus norvegicus
Synonyms:
Aconitase, Aconitate hydratase, mitochondrial, Citrate hydro-lyase
- Effects of hepatocellular iron imbalance on nitric oxide and reactive oxygen intermediates production in a model of sepsis. Jung, M., Drapier, J.C., Weidenbach, H., Renia, L., Oliveira, L., Wang, A., Beger, H.G., Nussler, A.K. J. Hepatol. (2000)
- Manganese inhibits mitochondrial aconitase: a mechanism of manganese neurotoxicity. Zheng, W., Ren, S., Graziano, J.H. Brain Res. (1998)
- Alteration of iron homeostasis following chronic exposure to manganese in rats. Zheng, W., Zhao, Q., Slavkovich, V., Aschner, M., Graziano, J.H. Brain Res. (1999)
- Short-term hyperglycemia produces oxidative damage and apoptosis in neurons. Vincent, A.M., McLean, L.L., Backus, C., Feldman, E.L. FASEB J. (2005)
- Requirement for superoxide in excitotoxic cell death. Patel, M., Day, B.J., Crapo, J.D., Fridovich, I., McNamara, J.O. Neuron (1996)
- Non-heme iron protein: a potential target of nitric oxide in acute cardiac allograft rejection. Pieper, G.M., Halligan, N.L., Hilton, G., Konorev, E.A., Felix, C.C., Roza, A.M., Adams, M.B., Griffith, O.W. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione. Bai, J., Cederbaum, A.I. J. Biol. Chem. (2006)
- Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. Echtay, K.S., Murphy, M.P., Smith, R.A., Talbot, D.A., Brand, M.D. J. Biol. Chem. (2002)
- Heat shock-induced attenuation of hydroxyl radical generation and mitochondrial aconitase activity in cardiac H9c2 cells. Ilangovan, G., Venkatakrishnan, C.D., Bratasz, A., Osinbowale, S., Cardounel, A.J., Zweier, J.L., Kuppusamy, P. Am. J. Physiol., Cell Physiol. (2006)
- Modulation of mitochondrial function by hydrogen peroxide. Nulton-Persson, A.C., Szweda, L.I. J. Biol. Chem. (2001)
- Islet beta-cell apoptosis triggered in vivo by interleukin-1beta is not related to the inducible nitric oxide synthase pathway: evidence for mitochondrial function impairment and lipoperoxidation. Todaro, M., Di Gaudio, F., Lavitrano, M., Stassi, G., Papaccio, G. Endocrinology (2003)
- Redox-dependent modulation of aconitase activity in intact mitochondria. Bulteau, A.L., Ikeda-Saito, M., Szweda, L.I. Biochemistry (2003)
- Reversible inactivation of superoxide-sensitive aconitase in Abeta1-42-treated neuronal cell lines. Longo, V.D., Viola, K.L., Klein, W.L., Finch, C.E. J. Neurochem. (2000)
- Aconitase activity, citrate oxidation, and zinc inhibition in rat ventral prostate. Costello, L.C., Franklin, R.B. Enzyme (1981)
- Aconitase activity in rat liver. Konstantinova, S.G., Russanov, E.M. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1996)
- Effect of clofibrate treatment on aconitase activity in rat liver and other tissues. Antonenkov, V.D., Panchenko, L.F. Int. J. Biochem. (1985)
- Zinc inhibition of mitochondrial aconitase and its importance in citrate metabolism of prostate epithelial cells. Costello, L.C., Liu, Y., Franklin, R.B., Kennedy, M.C. J. Biol. Chem. (1997)
- Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity. Bulteau, A.L., O'Neill, H.A., Kennedy, M.C., Ikeda-Saito, M., Isaya, G., Szweda, L.I. Science (2004)
- Interleukin-1 beta-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase. Welsh, N., Eizirik, D.L., Bendtzen, K., Sandler, S. Endocrinology (1991)
- High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis. Relling, D.P., Esberg, L.B., Fang, C.X., Johnson, W.T., Murphy, E.J., Carlson, E.C., Saari, J.T., Ren, J. J. Hypertens. (2006)
- Antioxidant treatment normalizes nitric oxide production, renal sodium handling and blood pressure in experimental hyperleptinemia. Beltowski, J., Wójcicka, G., Jamroz-Wiśniewska, A., Borkowska, E., Marciniak, A. Life Sci. (2005)
- Catecholamine-induced vascular wall growth is dependent on generation of reactive oxygen species. Bleeke, T., Zhang, H., Madamanchi, N., Patterson, C., Faber, J.E. Circ. Res. (2004)
- Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain. Kim, S.Y., Marekov, L., Bubber, P., Browne, S.E., Stavrovskaya, I., Lee, J., Steinert, P.M., Blass, J.P., Beal, M.F., Gibson, G.E., Cooper, A.J. Neurochem. Res. (2005)
- Resolution of rat mitochondrial matrix proteins by two-dimensional polyacrylamide gel electrophoresis. Henslee, J.G., Srere, P.A. J. Biol. Chem. (1979)
- Hypoxic reperfusion of the ischemic heart and oxygen radical generation. Angelos, M.G., Kutala, V.K., Torres, C.A., He, G., Stoner, J.D., Mohammad, M., Kuppusamy, P. Am. J. Physiol. Heart Circ. Physiol. (2006)