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Gene Review:

su(w[a]) - suppressor of white-apricot

Drosophila melanogaster

Synonyms: CG3019, DmSWAP, Dmel\CG3019, EG:BACR7A4.10, Protein suppressor of white apricot, ...

Mount, S.M. et al., Mancebo, R. et al., Li, H. et al., Sarkissian, M. et al., Zachar, Z. et al., et al.

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High impact information on su(w[a])

Two unrelated pre-mRNA splicing regulators-suppressor-of-white-apricot (su(wa)) and transformer (tra)-contain distinctive, approximately 120 amino acid arginine/serine (RS)-rich domains [1].
These arginine-rich regions contain stretches of arginine-serine dipeptides like those found in transformer, transformer-2, and suppressor-of-white-apricot proteins, all of which have been identified as regulators of mRNA splicing in Drosophila melanogaster [2].
DmSWAP was formally defined as an alternative splicing regulator by studies showing that it autoregulates splicing of its own pre-mRNA [3].
Analysis of autoregulation at the level of pre-mRNA splicing of the suppressor-of-white-apricot gene in Drosophila [4].
The eye color phenotype of white-apricot (wa), a mutant allele of the white locus caused by the insertion of the transposable element copia into a small intron, is suppressed by the extragenic suppressor suppressor-of-white-apricot (su(wa] and enhanced by the extragenic enhancers suppressor-of-forked su(f] and Enhancer-of-white-apricot (E(wa] [5].

Analytical, diagnostic and therapeutic context of su(w[a])

Molecular cloning and genetic analysis of the suppressor-of-white-apricot locus from Drosophila melanogaster [6].

References

Arginine/serine-rich domains of the su(wa) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicing. Li, H., Bingham, P.M. Cell (1991) [Pubmed]
Structure and expression of the Drosophila melanogaster gene for the U1 small nuclear ribonucleoprotein particle 70K protein. Mancebo, R., Lo, P.C., Mount, S.M. Mol. Cell. Biol. (1990) [Pubmed]
The mammalian homolog of suppressor-of-white-apricot regulates alternative mRNA splicing of CD45 exon 4 and fibronectin IIICS. Sarkissian, M., Winne, A., Lafyatis, R. J. Biol. Chem. (1996) [Pubmed]
Analysis of autoregulation at the level of pre-mRNA splicing of the suppressor-of-white-apricot gene in Drosophila. Zachar, Z., Chou, T.B., Kramer, J., Mims, I.P., Bingham, P.M. Genetics (1994) [Pubmed]
Partial revertants of the transposable element-associated suppressible allele white-apricot in Drosophila melanogaster: structures and responsiveness to genetic modifiers. Mount, S.M., Green, M.M., Rubin, G.M. Genetics (1988) [Pubmed]
Molecular cloning and genetic analysis of the suppressor-of-white-apricot locus from Drosophila melanogaster. Zachar, Z., Garza, D., Chou, T.B., Goland, J., Bingham, P.M. Mol. Cell. Biol. (1987) [Pubmed]

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