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Gene Review:

HLA-DOB - major histocompatibility complex, class II...

Homo sapiens

Synonyms: HLA class II histocompatibility antigen, DO beta chain, MHC class II antigen DOB

Nagarajan, U.M. et al., Liljedahl, M. et al., Fallas, J.L. et al., Naruse, T.K. et al.

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High impact information on HLA-DOB

The murine MHC class II molecule H2-O is expressed in B-cells and in thymic epithelium but the human equivalent, HLA-DO (DO), has not been detected, though the corresponding genes, HLA-DNA and HLA-DOB, are well known [1].
The combined data demonstrate that HLA-DOB levels are increased by CIITA, and that this difference has an impact on the overall level of HLA-DO expression [2].
Class II transactivator is required for maximal expression of HLA-DOB in B cells [2].
The HLA-DOB gene displays limited polymorphism with only one amino acid substitution [3].
The HLA-DOB gene has been identified in other mammals, and their nucleotide sequences are well conserved [3].

Anatomical context of HLA-DOB

To further evaluate the role of DO in Ag processing and presentation, we generated transgenic mice that expressed the human HLA-DOA and HLA-DOB genes under the control of a dendritic cell (DC)-specific promoter [4].

Other interactions of HLA-DOB

HLA-DO, encoded by the HLA-DOA and HLA-DOB genes, has been shown to function as a modulator of Ag presentation [2].

References

HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport. Liljedahl, M., Kuwana, T., Fung-Leung, W.P., Jackson, M.R., Peterson, P.A., Karlsson, L. EMBO J. (1996) [Pubmed]
Class II transactivator is required for maximal expression of HLA-DOB in B cells. Nagarajan, U.M., Lochamy, J., Chen, X., Beresford, G.W., Nilsen, R., Jensen, P.E., Boss, J.M. J. Immunol. (2002) [Pubmed]
The HLA-DOB gene displays limited polymorphism with only one amino acid substitution. Naruse, T.K., Kawata, H., Inoko, H., Isshiki, G., Yamano, K., Hino, M., Tatsumi, N. Tissue Antigens (2002) [Pubmed]
Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation. Fallas, J.L., Tobin, H.M., Lou, O., Guo, D., Sant'Angelo, D.B., Denzin, L.K. J. Immunol. (2004) [Pubmed]

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BOLA-DOB	Bos taurus
DLA-DOB	Canis lupus familiaris
MAMU-DOB	Macaca mulatta
H2-Ob	Mus musculus
PATR-DOB	Pan troglodytes
RT1-DOb	Rattus norvegicus

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