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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Hr4  -  CG43934 gene product from transcript...

Drosophila melanogaster

Synonyms: CG16902, CG3600, CG42527, CG43692, CG43934, ...
 
 
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High impact information on Hr4

  • In addition, we show that DHR4 plays a central role in the genetic cascades triggered by the steroid hormone ecdysone at the onset of metamorphosis, acting as both a repressor of the early ecdysone-induced regulatory genes and an inducer of the betaFTZ-F1 midprepupal competence factor [1].
  • A PCR approach has been used to isolate, from Bombyx mori, a cDNA encoding a novel orphan receptor (GRF) that is most closely related to Bombyx betaFTZ-F1 and to the vertebrate germ cell nuclear factor [2].

References

  1. The ecdysone-induced DHR4 orphan nuclear receptor coordinates growth and maturation in Drosophila. King-Jones, K., Charles, J.P., Lam, G., Thummel, C.S. Cell (2005) [Pubmed]
  2. Characterization and DNA-binding properties of GRF, a novel monomeric binding orphan receptor related to GCNF and betaFTZ-F1. Charles, J.P., Shinoda, T., Chinzei, Y. Eur. J. Biochem. (1999) [Pubmed]
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