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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Vinc  -  Vinculin

Drosophila melanogaster

Synonyms: CG3299, CT11081, Dmel\CG3299, Dmvincp, EG:103B4.1, ...
 
 
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High impact information on Vinc

  • In addition to white, Rga also affects the expression of several other tested genes, with one of them, Vinculin, being regulated in a strong sex-specific manner [1].
  • The X chromosome rearrangement In(1LR)pn2a was found to disrupt Vinc so that the coding sequence is interrupted by the (AAGAG)n satellite DNA [2].
  • Drosophila vinculin is highly homologous in its N- and C-terminal domains both to mammalian and nematode vinculins, and contains internal repeats and proline-rich region typical for vinculins [2].
  • Antibodies directed against alpha-actinin and vinculin recognized single protein bands on immunoblots of octopus retinal extract with molecular weights comparable to the same proteins in other tissues [3].
 

Analytical, diagnostic and therapeutic context of Vinc

  • Molecular cloning revealed the presence of a new junction between euchromatin and AAGAG satellite sequences and demonstrated that the euchromatic breakpoint of In(1LR)pn2a lies in the vinculin gene [4].

References

  1. Regena (Rga), a Drosophila homolog of the global negative transcriptional regulator CDC36 (NOT2) from yeast, modifies gene expression and suppresses position effect variegation. Frolov, M.V., Benevolenskaya, E.V., Birchler, J.A. Genetics (1998) [Pubmed]
  2. Vinculin gene is non-essential in Drosophila melanogaster. Alatortsev, V.E., Kramerova, I.A., Frolov, M.V., Lavrov, S.A., Westphal, E.D. FEBS Lett. (1997) [Pubmed]
  3. Identification and immunolocalization of actin cytoskeletal components in light- and dark-adapted octopus retinas. De Velasco, B., Martinez, J.M., Ochoa, G.H., Miller, A.M., Clark, Y.M., Matsumoto, B., Robles, L.J. Exp. Eye Res. (1999) [Pubmed]
  4. Position-effect variegation in Drosophila melanogaster X chromosome inversion with a breakpoint in a satellite block and its suppression in a secondary rearrangement. Tolchkov, E.V., Kramerova, I.A., Lavrov, S.A., Rasheva, V.I., Bonaccorsi, S., Alatortsev, V.E., Gvozdev, V.A. Chromosoma (1997) [Pubmed]
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