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Gene Review

Actn  -  alpha actinin

Drosophila melanogaster

Synonyms: ACTN, Alpha-actinin, sarcomeric, CG4376, CT14163, CT14232, ...
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High impact information on Actn


Biological context of Actn

  • We discuss these phenotypes in the light of presumed in vivo alpha-actinin functions [4].
  • Molecular genetics of Drosophila alpha-actinin: mutant alleles disrupt Z disc integrity and muscle insertions [4].
  • Allelic but less severely affected fliA mutants are apparently due to point mutations, and develop into adults having thoracic muscle abnormalities [4].
  • In all four cases, hemizygous mutants complete embryogenesis and do not die until the second day of larval growth, signifying that either the role of alpha-actinin in nonmuscle cells is redundant or that a distinct and only distantly related gene encodes the non-muscle isoform [4].
  • Successful rescue indicated that alternative splicing, which also generates larval muscle and non-muscle isoforms, was not essential for viability and that there were no strict spatial or temporal requirements for alpha-actinin expression [5].

Anatomical context of Actn


Associations of Actn with chemical compounds


Co-localisations of Actn

  • RESULTS AND CONCLUSIONS: In the first step of assembly, projectin immunolocalization appears as random aggregates colocalizing with alpha-actinin, kettin and Z(210), as well as, F-actin [11].

Regulatory relationships of Actn


Other interactions of Actn

  • Thirdly, the length of alpha-actinin was modified by adding a 114 amino acid structural repeat from alpha-spectrin to the center of the rod domain of alpha-actinin [5].
  • Analysis of mutations that affect expression of integrins and alpha-actinin, key components of these structures, also failed to perturb Mlp84B distribution [13].
  • Sequence similarity of the amino-terminal domain of Drosophila beta spectrin to alpha actinin and dystrophin [14].
  • On Lowicryl sections of asynchronous flight muscle, indirect immunogold staining has localized alpha-actinin and the 210-kD protein throughout the matrix of the Z-band, projectin between the Z- and A-bands, and the 400/600-kD components at the I-band/Z-band junction [15].
  • Spectrin and the related proteins dystrophin and alpha-actinin consist largely of repeated motifs of 100-120 residues [16].


  1. Kettin, a major source of myofibrillar stiffness in Drosophila indirect flight muscle. Kulke, M., Neagoe, C., Kolmerer, B., Minajeva, A., Hinssen, H., Bullard, B., Linke, W.A. J. Cell Biol. (2001) [Pubmed]
  2. Kettin, a large modular protein in the Z-disc of insect muscles. Lakey, A., Labeit, S., Gautel, M., Ferguson, C., Barlow, D.P., Leonard, K., Bullard, B. EMBO J. (1993) [Pubmed]
  3. Perturbations of Drosophila alpha-actinin cause muscle paralysis, weakness, and atrophy but do not confer obvious nonmuscle phenotypes. Roulier, E.M., Fyrberg, C., Fyrberg, E. J. Cell Biol. (1992) [Pubmed]
  4. Molecular genetics of Drosophila alpha-actinin: mutant alleles disrupt Z disc integrity and muscle insertions. Fyrberg, E., Kelly, M., Ball, E., Fyrberg, C., Reedy, M.C. J. Cell Biol. (1990) [Pubmed]
  5. Genetic analysis of the requirements for alpha-actinin function. Dubreuil, R.R., Wang, P. J. Muscle Res. Cell. Motil. (2000) [Pubmed]
  6. Drosophila non-muscle alpha-actinin is localized in nurse cell actin bundles and ring canals, but is not required for fertility. Wahlström, G., Lahti, V.P., Pispa, J., Roos, C., Heino, T.I. Mech. Dev. (2004) [Pubmed]
  7. High-resolution field emission scanning electron microscope imaging of internal cell structures after Epon extraction from sections: a new approach to correlative ultrastructural and immunocytochemical studies. Ris, H., Malecki, M. J. Struct. Biol. (1993) [Pubmed]
  8. Regulation of alternative splicing of alpha-actinin transcript by Bruno-like proteins. Suzuki, H., Jin, Y., Otani, H., Yasuda, K., Inoue, K. Genes Cells (2002) [Pubmed]
  9. Functional and ultrastructural effects of a missense mutation in the indirect flight muscle-specific actin gene of Drosophila melanogaster. Sparrow, J., Reedy, M., Ball, E., Kyrtatas, V., Molloy, J., Durston, J., Hennessey, E., White, D. J. Mol. Biol. (1991) [Pubmed]
  10. Laminin-dependent integrin clustering with tyrosine-phosphorylated molecules in a Drosophila neuronal cell line. Takagi, Y., Ui-Tei, K., Miyake, T., Hirohashi, S. Neurosci. Lett. (1998) [Pubmed]
  11. Assembly of the giant protein projectin during myofibrillogenesis in Drosophila indirect flight muscles. Ayme-Southgate, A., Bounaix, C., Riebe, T.E., Southgate, R. BMC Cell Biol. (2004) [Pubmed]
  12. Drosophila alpha-actinin in ovarian follicle cells is regulated by EGFR and Dpp signalling and required for cytoskeletal remodelling. Wahlstr??m, G., Norokorpi, H.L., Heino, T.I. Mech. Dev. (2006) [Pubmed]
  13. Muscle LIM proteins are associated with muscle sarcomeres and require dMEF2 for their expression during Drosophila myogenesis. Stronach, B.E., Renfranz, P.J., Lilly, B., Beckerle, M.C. Mol. Biol. Cell (1999) [Pubmed]
  14. Sequence similarity of the amino-terminal domain of Drosophila beta spectrin to alpha actinin and dystrophin. Byers, T.J., Husain-Chishti, A., Dubreuil, R.R., Branton, D., Goldstein, L.S. J. Cell Biol. (1989) [Pubmed]
  15. Characterization of components of Z-bands in the fibrillar flight muscle of Drosophila melanogaster. Saide, J.D., Chin-Bow, S., Hogan-Sheldon, J., Busquets-Turner, L., Vigoreaux, J.O., Valgeirsdottir, K., Pardue, M.L. J. Cell Biol. (1989) [Pubmed]
  16. Phasing the conformational unit of spectrin. Winograd, E., Hume, D., Branton, D. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
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