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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Sos1  -  Son of sevenless homolog 1 (Drosophila)

Rattus norvegicus

 
 
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High impact information on Sos1

  • The first peak of activation of p21ras, at 2-5 min, is mediated by immediate association of phosphorylated Shc with the guanosine exchange factor Sos1 via the adaptor protein Grb2 [1].
  • Calcium influx through L-type VSCCs leads to tyrosine phosphorylation of the adaptor protein Shc and its association with the adaptor protein Grb2, which is bound to the guanine nucleotide exchange factor Sos1 [2].
  • E3b1, a binding partner of Eps8, plays a critical role in receptor tyrosine kinase (RTK)-mediated Rac activation by facilitating the interaction of Eps8 with Sos-1 and the consequent activation of the Rac-specific guanine nucleotide exchange factor activity of Sos-1 [3].
  • Furthermore, the GTP binding protein Sos1 was found to dissociate from Shc upon MAFA clustering, suggesting that SHIP and Sos1 compete for Shc binding [4].
  • Post-synaptic localization of RSK1 and Sos1 was confirmed by immunohistochemical examination at the electron microscopic level: the two immunoreactivities were localized in the PSDs, both in the spines and dendrites [5].

References

  1. Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase. Foschi, M., Chari, S., Dunn, M.J., Sorokin, A. EMBO J. (1997) [Pubmed]
  2. Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels. Rosen, L.B., Greenberg, M.E. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. Pak regulates calpain-dependent degradation of E3b1. Chi, S., Chang, S., Park, D. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  4. Clustering the mast cell function-associated antigen (MAFA) leads to tyrosine phosphorylation of p62Dok and SHIP and affects RBL-2H3 cell cycle. Abramson, J., Pecht, I. Immunol. Lett. (2002) [Pubmed]
  5. Presence of up-stream and downstream components of a mitogen-activated protein kinase pathway in the PSD of the rat forebrain. Suzuki, T., Mitake, S., Murata, S. Brain Res. (1999) [Pubmed]
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