Gene Review:
SOS1 - son of sevenless homolog 1 (Drosophila)
Homo sapiens
Synonyms:
GF1, GGF1, GINGF, HGF, NS4, ...
Pennacchio,
Bar-Sagi,
Yadav,
Vasta,
Siguero,
Carta,
Marazita,
Gorry,
Dallapiccola,
Gelb,
Zhang,
Osada,
Bristow,
Pandit,
Curry,
Lepri,
Zhu,
Martin,
Digilio,
Schackwitz,
Sarkozy,
Hart,
Pallos,
Fodale,
Cortelli,
Zampino,
Neri,
Gibson,
Zhao,
Saji,
Hart,
Marks,
Tartaglia,
Oishi,
Martinelli,
Ustaszewska,
Cooper,
- Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Tartaglia, M., Pennacchio, L.A., Zhao, C., Yadav, K.K., Fodale, V., Sarkozy, A., Pandit, B., Oishi, K., Martinelli, S., Schackwitz, W., Ustaszewska, A., Martin, J., Bristow, J., Carta, C., Lepri, F., Neri, C., Vasta, I., Gibson, K., Curry, C.J., Siguero, J.P., Digilio, M.C., Zampino, G., Dallapiccola, B., Bar-Sagi, D., Gelb, B.D. Nat. Genet. (2007)
- A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1. Hart, T.C., Zhang, Y., Gorry, M.C., Hart, P.S., Cooper, M., Marazita, M.L., Marks, J.M., Cortelli, J.R., Pallos, D. Am. J. Hum. Genet. (2002)
- The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains. Zheng, J., Chen, R.H., Corblan-Garcia, S., Cahill, S.M., Bar-Sagi, D., Cowburn, D. J. Biol. Chem. (1997)
- Tumor HGF lacks prognostic significance in Mexican breast cancer patients. Pruefer, F.G., Unger-Salda??a, K., Mohamier, L., Ram??rez, M., Su??rez, J., Ramirez, M.T., Maldonado, V., Mel??ndez-Zajgla, J. J. Exp. Clin. Cancer Res. (2006)
- Germ line gain of function with SOS1 mutation in hereditary gingival fibromatosis. Jang, S.I., Lee, E.J., Hart, P.S., Ramaswami, M., Pallos, D., Hart, T.C. J. Biol. Chem. (2007)
- Signal transduction abnormalities in Alzheimer's disease: evidence of a pathogenic stimuli. McShea, A., Zelasko, D.A., Gerst, J.L., Smith, M.A. Brain Res. (1999)
- The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5. Lanzetti, L., Rybin, V., Malabarba, M.G., Christoforidis, S., Scita, G., Zerial, M., Di Fiore, P.P. Nature (2000)
- Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Chardin, P., Camonis, J.H., Gale, N.W., van Aelst, L., Schlessinger, J., Wigler, M.H., Bar-Sagi, D. Science (1993)
- {beta}4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth. Bertotti, A., Comoglio, P.M., Trusolino, L. J. Cell Biol. (2006)
- Chronic exposure to fulvestrant promotes overexpression of the c-Met receptor in breast cancer cells: implications for tumour-stroma interactions. Hiscox, S., Jordan, N.J., Jiang, W., Harper, M., McClelland, R., Smith, C., Nicholson, R.I. Endocr. Relat. Cancer (2006)
- Localization, genomic organization, and alternative transcription of a novel human SAM-dependent methyltransferase gene on chromosome 2p22-->p21. Zhang, Y., Gorry, M.C., Hart, P.S., Pettenati, M.J., Wang, L., Marks, J.J., Lu, X., Hart, T.C. Cytogenet. Cell Genet. (2001)
- Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking. Robinson, A., Gibbins, J., Rodríguez-Liñares, B., Finan, P.M., Wilson, L., Kellie, S., Findell, P., Watson, S.P. Blood (1996)
- Molecular genetic perspectives on cross-talk and specificity in abiotic stress signalling in plants. Chinnusamy, V., Schumaker, K., Zhu, J.K. J. Exp. Bot. (2004)
- Genetic heterogeneity of gingival fibromatosis on chromosome 2p. Shashi, V., Pallos, D., Pettenati, M.J., Cortelli, J.R., Fryns, J.P., von Kap-Herr, C., Hart, T.C. J. Med. Genet. (1999)
- Characterization of fibroblasts with son of sevenless-1 mutation. Lee, E.J., Jang, S.I., Pallos, D., Kather, J., Hart, T.C. J. Dent. Res. (2006)
- Regulation of ion homeostasis under salt stress. Zhu, J.K. Curr. Opin. Plant Biol. (2003)
- Expression of alternative forms of Ras exchange factors GRF and SOS1 in different human tissues and cell lines. Guerrero, C., Rojas, J.M., Chedid, M., Esteban, L.M., Zimonjic, D.B., Popescu, N.C., Font de Mora, J., Santos, E. Oncogene (1996)
- The T-cell antigen receptor utilizes Lck, Raf-1, and MEK-1 for activating mitogen-activated protein kinase. Evidence for the existence of a second protein kinase C-dependent pathway in an Lck-negative Jurkat cell mutant. Gupta, S., Weiss, A., Kumar, G., Wang, S., Nel, A. J. Biol. Chem. (1994)
- Studying multisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: Application to adaptor protein complexes in cell signaling. Houtman, J.C., Brown, P.H., Bowden, B., Yamaguchi, H., Appella, E., Samelson, L.E., Schuck, P. Protein Sci. (2007)
- New approach to cancer therapy: the application of signal transduction to anti-cancer drug. Osada, S., Saji, S. Current medicinal chemistry. Anti-cancer agents. (2003)
- Direct interaction of SOS1 Ras exchange protein with the SH3 domain of phospholipase C-gamma1. Kim, M.J., Chang, J.S., Park, S.K., Hwang, J.I., Ryu, S.H., Suh, P.G. Biochemistry (2000)
- The two SH2-domain-containing inositol 5-phosphatases SHIP1 and SHIP2 are coexpressed in human T lymphocytes. Bruyns, C., Pesesse, X., Moreau, C., Blero, D., Erneux, C. Biol. Chem. (1999)
- The membrane immunoglobulin receptor utilizes a Shc/Grb2/hSOS complex for activation of the mitogen-activated protein kinase cascade in a B-cell line. Kumar, G., Wang, S., Gupta, S., Nel, A. Biochem. J. (1995)
- Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2. Corbalan-Garcia, S., Yang, S.S., Degenhardt, K.R., Bar-Sagi, D. Mol. Cell. Biol. (1996)
- Differential interactions of human Sos1 and Sos2 with Grb2. Yang, S.S., Van Aelst, L., Bar-Sagi, D. J. Biol. Chem. (1995)
- Normal p21Ras/MAP kinase pathway expression and function in PBMC from patients with polycystic ovary disease. Buchs, A., Chagag, P., Weiss, M., Kish, E., Levinson, R., Aharoni, D., Rapoport, M.J. Int. J. Mol. Med. (2004)
- Interaction of filamin A with the insulin receptor alters insulin-dependent activation of the mitogen-activated protein kinase pathway. He, H.J., Kole, S., Kwon, Y.K., Crow, M.T., Bernier, M. J. Biol. Chem. (2003)
- Guanine nucleotide exchange factors: activators of Ras superfamily proteins. Overbeck, A.F., Brtva, T.R., Cox, A.D., Graham, S.M., Huff, S.Y., Khosravi-Far, R., Quilliam, L.A., Solski, P.A., Der, C.J. Mol. Reprod. Dev. (1995)
- Decreased expression of the p21ras stimulatory factor hSOS in PBMC from inactive SLE patients. Rapoport, M.J., Mor, A., Amit, M., Rosenberg, R., Ramot, Y., Mizrachi, A., Wysenbeek, A.J. Lupus (1999)
- Isolated Sos1 PH domain exhibits germinal vesicle breakdown-inducing activity in Xenopus oocytes. Font de Mora, J., Guerrero, C., Mahadevan, D., Coque, J.J., Rojas, J.M., Esteban, L.M., Rebecchi, M., Santos, E. J. Biol. Chem. (1996)