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Gene Review

Lrpprc  -  leucine-rich pentatricopeptide repeat...

Rattus norvegicus

Synonyms: 130 kDa leucine-rich protein, LRP 130, Leucine rich protein 157, Leucine-rich PPR motif-containing protein, mitochondrial, Lrp157, ...
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Disease relevance of Lrpprc

  • Moreover, the genetic basis of French-Canadian Leigh syndrome, which confers a loss of mitochondrial cytochrome c oxidase and is characterized by neurodegeneration, was recently mapped to a mutation in the LRPPRC gene [1].

High impact information on Lrpprc

  • Due to its molecular weight and significant amino acid identity with 'human leucine-rich protein 130'[leucine-rich pentatricopeptide motif containing (LRPPRC)], we termed the cDNA candidate leucine-rich protein 157 (rLRP157) [1].
  • Taken together with its expression in small-diameter sensory neurons, we hypothesize that rLRP157, the rat orthologue of the human LRPPRC, may play a role in the modulation of peripheral pain transduction and serve as a novel marker for nociceptor subtypes [1].


  1. Isolation of an mRNA binding protein homologue that is expressed in nociceptors. Eilers, H., Trilk, S.L., Lee, S.Y., Xue, Q., Jong, B.E., Moff, I., Levine, J.D., Schumacher, M.A. Eur. J. Neurosci. (2004) [Pubmed]
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