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Gene Review

Lrpprc  -  leucine-rich PPR-motif containing

Mus musculus

Synonyms: 130 kDa leucine-rich protein, 3110001K13Rik, C76645, Gp130, LRP 130, ...
 
 
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Disease relevance of Lrpprc

  • An rSV40 carrying SIVmac239 envelope glycoprotein gp130 cDNA (SV(gp130)) was given multiple times to BALB/c mice, with or without a prior priming inoculation using vaccinia virus carrying the same SIV envelope cDNA (VVenvSIV) [1].
 

High impact information on Lrpprc

  • Two glycoproteins, of 130,000 (gp130) and 150,000 (gp150) mol wt, were specifically immunoprecipitated from metabolically labeled lysates of mouse cell transformants and were shown to contain [35S]methionine-labeled tryptic peptides identical to those of analogous glycoproteins expressed in the donor human myeloid cell line [2].
  • Also, we used the Cre-loxP system to inactive GP130 specifically in germ cells and found that this resulted in a fertility defect in females [3].
  • GP130, the shared receptor for the LIF/IL6 cytokine family in the mouse, is not required for early germ cell differentiation, but is required cell-autonomously in oocytes for ovulation [3].
  • Cardiac gene expression was decreased for common hypertrophy-inducing proteins such as actin, collagen and GP130 pathways [4].
  • Expression of IL-6 receptor and GP130 in mouse bone marrow cells during osteoclast differentiation [5].
 

Associations of Lrpprc with chemical compounds

 

Biological context of Lrpprc

  • After six inoculations with SV(gp130), mice made detectable anti-gp130 antibody responses, but high levels of splenic and popliteal lymph node cytotoxic activity were apparent after as few as three injections of SV(gp130) (>40% specific lysis) [1].
 

Anatomical context of Lrpprc

  • The same gp130-expressing clone of P815 cells, labeled with 51Cr was used as targets for direct lymphocyte-mediated cytolytic assays using spleen and popliteal lymph node cells as effectors [1].
  • A single primary inoculation with VVenvSIV preceding SV(gp130) boosts significantly enhanced antibody responses against SIV gp130, but had little effect on cytotoxic lymphocyte responses [1].
 

Analytical, diagnostic and therapeutic context of Lrpprc

  • Sera from these mice were tested for antibodies binding gp130, applying a novel cell-based ELISA protocol that used as targets cloned P815 cells stably transfected with plasmid-derived gp130 cDNA [1].

References

  1. Immune responses against SIV envelope glycoprotein, using recombinant SV40 as a vaccine delivery vector. McKee, H.J., Strayer, D.S. Vaccine (2002) [Pubmed]
  2. Transfer and expression of the gene encoding a human myeloid membrane antigen (gp150). Look, A.T., Peiper, S.C., Rebentisch, M.B., Ashmun, R.A., Roussel, M.F., Rettenmier, C.W., Sherr, C.J. J. Clin. Invest. (1985) [Pubmed]
  3. GP130, the shared receptor for the LIF/IL6 cytokine family in the mouse, is not required for early germ cell differentiation, but is required cell-autonomously in oocytes for ovulation. Molyneaux, K.A., Schaible, K., Wylie, C. Development (2003) [Pubmed]
  4. Gene expression profiling of alpha(1b)-adrenergic receptor-induced cardiac hypertrophy by oligonucleotide arrays. Yun, J., Zuscik, M.J., Gonzalez-Cabrera, P., McCune, D.F., Ross, S.A., Gaivin, R., Piascik, M.T., Perez, D.M. Cardiovasc. Res. (2003) [Pubmed]
  5. Expression of IL-6 receptor and GP130 in mouse bone marrow cells during osteoclast differentiation. Gao, Y., Morita, I., Maruo, N., Kubota, T., Murota, S., Aso, T. Bone (1998) [Pubmed]
  6. Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130. Cooper, M.P., Uldry, M., Kajimura, S., Arany, Z., Spiegelman, B.M. J. Biol. Chem. (2008) [Pubmed]
 
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