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Gene Review:

NP - nucleocapsid protein

Parainfluenza virus 5

Parks, G.D. et al., He, B. et al.

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Disease relevance of NP

The plasmid encoding the antigenome sequence was transfected into cells previously infected with recombinant vaccinia virus that expressed T7 RNA polymerase, together with helper plasmids that expressed the viral replication proteins, NP, P, and L, under the control of the T7 polymerase promoter [1].
Molecular cloning of the NP and L genes of simian virus 5: identification of highly conserved domains in paramyxovirus NP and L proteins [2].
Overall, the SV5 NP protein showed the highest degree of sequence identity with the NP proteins of parainfluenza type 2 virus (58%) and mumps virus (56%) [2].

High impact information on NP

A comparison of the amino acid sequences of 10 paramyxovirus NP proteins indicates a region of high sequence identity near the middle of the protein, and a C-terminal region which is enriched in negatively charged residues [2].
We have molecularly cloned and determined the nucleotide sequence of the 3' and 5' regions of the genomic RNA of the paramyxovirus simian virus 5 (SV5), including the 3' leader sequence, nucleocapsid protein (NP) gene, large (L) protein gene, and 5' anti-genomic leader (trailer) sequence [2].

References

Recovery of infectious SV5 from cloned DNA and expression of a foreign gene. He, B., Paterson, R.G., Ward, C.D., Lamb, R.A. Virology (1997) [Pubmed]
Molecular cloning of the NP and L genes of simian virus 5: identification of highly conserved domains in paramyxovirus NP and L proteins. Parks, G.D., Ward, C.D., Lamb, R.A. Virus Res. (1992) [Pubmed]

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