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MeSH Review


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Disease relevance of Mumps


High impact information on Mumps

  • Although 15-minute skin reactions to schistosomal antigens remained unchanged, niridazole reduced or ablated positive 48-hour skin reactions to tuberculin (PPD), mumps and schistosome antigens in all patients tested six and 15 days after therapy began [6].
  • Candida and mumps antigens resulted in significantly more positive responses than did TT or PPD [7].
  • Antibodies against the mumps virus envelope glycoprotein, M-protein, and nucleoprotein could be demonstrated by immunoprecipitation and the antibody patterns in serum and CSF were similar [8].
  • Iodide mumps after repeated exposure to iodinated contrast media [9].
  • To our knowledge, this is the first report of mumps virus infection related to a disorder similar to juvenile rheumatoid arthritis [10].

Chemical compound and disease context of Mumps


Biological context of Mumps


Anatomical context of Mumps


Gene context of Mumps

  • Like other paramyxoviruses in the genus Rubulavirus, mumps virus catalyzes the proteasomal degradation of cellular STAT1 protein, a means for escaping antiviral responses initiated by alpha/beta and gamma interferons [17].
  • We demonstrate that mumps virus also eliminates cellular STAT3, a protein that mediates transcriptional responses to cytokines, growth factors, nonreceptor tyrosine kinases, and a variety of oncogenic stimuli [17].
  • Simian virus 5 (SV5) targets STAT1, human parainfluenza virus 2 targets STAT2, and mumps virus targets both STAT1 and STAT3 [25].
  • We have defined the T cell reactivities to measles and mumps virus and to MAG in an immunospot assay which is based on the detection of secretion of interferon-gamma (IFN-gamma) by single cells upon stimulation with specific antigen in short term cultures [26].
  • Mumps viral antigen induced primarily IFN-alpha regardless of the immunological status of the donor [27].

Analytical, diagnostic and therapeutic context of Mumps


  1. Diagnosis and prognosis in colon cancer based on a profile in immune reactivity. Lurie, B.B., Bull, D.M., Zamcheck, N., Steward, A.M., Helms, R.A. J. Natl. Cancer Inst. (1975) [Pubmed]
  2. Factors affecting uptake of childhood immunisation: a Bayesian synthesis of qualitative and quantitative evidence. Roberts, K.A., Dixon-Woods, M., Fitzpatrick, R., Abrams, K.R., Jones, D.R. Lancet (2002) [Pubmed]
  3. Incidence of tuberculosis in the United States among HIV-infected persons. The Pulmonary Complications of HIV Infection Study Group. Markowitz, N., Hansen, N.I., Hopewell, P.C., Glassroth, J., Kvale, P.A., Mangura, B.T., Wilcosky, T.C., Wallace, J.M., Rosen, M.J., Reichman, L.B. Ann. Intern. Med. (1997) [Pubmed]
  4. Viral infection of the myocardium in endocardial fibroelastosis. Molecular evidence for the role of mumps virus as an etiologic agent. Ni, J., Bowles, N.E., Kim, Y.H., Demmler, G., Kearney, D., Bricker, J.T., Towbin, J.A. Circulation (1997) [Pubmed]
  5. Inclusion body myositis: the mumps virus hypothesis. Nishino, H., Engel, A.G., Rima, B.K. Ann. Neurol. (1989) [Pubmed]
  6. Suppression of delayed hypersensitivity in schistosome-infected patients by niridazole. Webster, L.T., Butterworth, A.E., Mahmoud, A.A., Mngola, E.N., Warren, K.S. N. Engl. J. Med. (1975) [Pubmed]
  7. Tetanus toxoid as an antigen for delayed cutaneous hypersensitivity. Delafuente, J.C., Eisenberg, J.D., Hoelzer, D.R., Slavin, R.G. JAMA (1983) [Pubmed]
  8. Chronic encephalomyelitis with specific increase in intrathecal mumps antibodies. Vaheri, A., Julkunen, I., Koskiniemi, M.L. Lancet (1982) [Pubmed]
  9. Iodide mumps after repeated exposure to iodinated contrast media. Cohen, J.C., Roxe, D.M., Said, R., Cummins, G. Lancet (1980) [Pubmed]
  10. Mumps arthritis: unusual presentation as adult Still's disease. Gordon, S.C., Lauter, C.B. Ann. Intern. Med. (1982) [Pubmed]
  11. Differential up-regulation of HLA class I molecules on neuronal and glial cell lines by virus infection correlates with differential induction of IFN-beta. Dhib-Jalbut, S.S., Xia, Q., Drew, P.D., Swoveland, P.T. J. Immunol. (1995) [Pubmed]
  12. Cell-mediated immune response to mumps virus infection in man. Chiba, Y., Dzierba, J.L., Morag, A., Ogra, P.L. J. Immunol. (1976) [Pubmed]
  13. Immunology of sarcoidosis. James, D.G., Neville, E., Walker, A. Am. J. Med. (1975) [Pubmed]
  14. Mumps virus decreases testosterone production and gamma interferon-induced protein 10 secretion by human leydig cells. Le Goffic, R., Mouchel, T., Ruffault, A., Patard, J.J., Jégou, B., Samson, M. J. Virol. (2003) [Pubmed]
  15. Mumps infection and insulin-dependent diabetes mellitus (IDDM). Ratzmann, K.P., Strese, J., Witt, S., Berling, H., Keilacker, H., Michaelis, D. Diabetes Care (1984) [Pubmed]
  16. mRNA sequence and deduced amino acid sequence of the mumps virus small hydrophobic protein gene. Elango, N., Kövamees, J., Varsanyi, T.M., Norrby, E. J. Virol. (1989) [Pubmed]
  17. STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling. Ulane, C.M., Rodriguez, J.J., Parisien, J.P., Horvath, C.M. J. Virol. (2003) [Pubmed]
  18. Characterization of nucleocapsid binding by the measles virus and mumps virus phosphoproteins. Kingston, R.L., Baase, W.A., Gay, L.S. J. Virol. (2004) [Pubmed]
  19. Association of mumps virus V protein with RACK1 results in dissociation of STAT-1 from the alpha interferon receptor complex. Kubota, T., Yokosawa, N., Yokota, S., Fujii, N. J. Virol. (2002) [Pubmed]
  20. Responses of lymphocytes of patients with rheumatoid arthritis to IgG modified by oxygen radicals or peroxynitrite. Grinnell, S., Yoshida, K., Jasin, H.E. Arthritis Rheum. (2005) [Pubmed]
  21. Genetic, immunologic, and environmental heterogeneity of IDDM. Incidence and 12-mo follow-up of an Italian population. Pagano, G., Cavallo-Perin, P., Cavalot, F., Dall'Omo, A.M., Masciola, P., Suriani, R., Amoroso, A., Curtoni, S.E., Borelli, I., Lenti, G. Diabetes (1987) [Pubmed]
  22. Modulation of Ia-like antigen expression and antigen-presenting activity of human monocytes by endotoxin and zymosan A. Yem, A.W., Parmely, M.J. J. Immunol. (1981) [Pubmed]
  23. In vitro analysis of experimental avian viral myocarditis. Davis, C.W., St Geme, J.W., Dufour, F.D., Martin, H.L. J. Infect. Dis. (1975) [Pubmed]
  24. Nested PCR for rapid detection of mumps virus in cerebrospinal fluid from patients with neurological diseases. Poggio, G.P., Rodriguez, C., Cisterna, D., Freire, M.C., Cello, J. J. Clin. Microbiol. (2000) [Pubmed]
  25. Composition and assembly of STAT-targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain. Ulane, C.M., Kentsis, A., Cruz, C.D., Parisien, J.P., Schneider, K.L., Horvath, C.M. J. Virol. (2005) [Pubmed]
  26. Virus-reactive and autoreactive T cells are accumulated in cerebrospinal fluid in multiple sclerosis. Link, H., Sun, J.B., Wang, Z., Xu, Z., Löve, A., Fredrikson, S., Olsson, T. J. Neuroimmunol. (1992) [Pubmed]
  27. Cytomegalovirus (CMV): specific lymphokine production in congenital CMV infection. Gehrz, R.C., Leonard, T.E. Clin. Exp. Immunol. (1985) [Pubmed]
  28. Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association. Taylor, B., Miller, E., Farrington, C.P., Petropoulos, M.C., Favot-Mayaud, I., Li, J., Waight, P.A. Lancet (1999) [Pubmed]
  29. Etiology of measles- and rubella-like illnesses in measles, mumps, and rubella-vaccinated children. Davidkin, I., Valle, M., Peltola, H., Hovi, T., Paunio, M., Roivainen, M., Linnavuori, K., Jokinen, S., Leinikki, P. J. Infect. Dis. (1998) [Pubmed]
  30. Genetic heterogeneity of mumps virus in the United Kingdom: identification of two new genotypes. Jin, L., Beard, S., Brown, D.W. J. Infect. Dis. (1999) [Pubmed]
  31. Sequence analysis of the mumps virus mRNA encoding the P protein. Elango, N., Kövamees, J., Norrby, E. Virology (1989) [Pubmed]
  32. Molecular cloning and sequence analysis of the mumps virus gene encoding the L protein and the trailer sequence. Okazaki, K., Tanabayashi, K., Takeuchi, K., Hishiyama, M., Okazaki, K., Yamada, A. Virology (1992) [Pubmed]
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