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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

L  -  RNA polymerase protein

Sendai virus

 
 
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Disease relevance of L

 

High impact information on L

  • A stuttering or slippage model to account for these events has been further refined to include a pressure which displaces the nascent strand in a given direction once it has disengaged from the template, and the similarities of this model to those which account for readthrough of cellular RNA polymerase transcription blocks are discussed [6].
  • The recombinant clones were probed first with radiolabeled products of an in vitro virion RNA polymerase reaction to locate early message clones and then with a probe from the viral genome 3' end to locate the most 3'-proximal clones [7].
  • Sendai virus RNA-dependent RNA polymerase L protein catalyzes cap methylation of virus-specific mRNA [1].
  • Competition between the Sendai virus N mRNA start site and the genome 3'-end promoter for viral RNA polymerase [8].
  • First, functional ribonucleoprotein complexes (RNPs) were recovered from SeV cloned cDNA defective in the F (envelope fusion protein) gene, in the presence of plasmids expressing nucleocapsid protein and viral RNA polymerase [9].
 

Biological context of L

 

Anatomical context of L

 

Regulatory relationships of L

  • A natural Sendai virus internal deletion defective interfering (DI) RNA, previously shown to encode a truncated NP protein and previously cloned under the control of the T7 RNA polymerase promoter, was expressed from plasmid and shown to replicate in cell tissue culture when the viral proteins NP, P, and L were coexpressed from cloned genes [15].
 

Other interactions of L

  • Using the two-hybrid system we have confirmed the previously identified P-L (RNA polymerase), NPo-P (encapsidation substrate), and P-P complexes and now demonstrate NP-NP and NPo-V protein interactions [16].

References

  1. Sendai virus RNA-dependent RNA polymerase L protein catalyzes cap methylation of virus-specific mRNA. Ogino, T., Kobayashi, M., Iwama, M., Mizumoto, K. J. Biol. Chem. (2005) [Pubmed]
  2. Phosphorylation of Sendai virus phosphoprotein by cellular protein kinase C zeta. Huntley, C.C., De, B.P., Banerjee, A.K. J. Biol. Chem. (1997) [Pubmed]
  3. Role of a highly conserved NH(2)-terminal domain of the human parainfluenza virus type 3 RNA polymerase. Malur, A.G., Choudhary, S.K., De, B.P., Banerjee, A.K. J. Virol. (2002) [Pubmed]
  4. Gene expression of nonsegmented negative strand RNA viruses. Banerjee, A.K., Barik, S., De, B.P. Pharmacol. Ther. (1991) [Pubmed]
  5. Chemical modification of nucleotide bases and mRNA editing depend on hexamer or nucleoprotein phase in Sendai virus nucleocapsids. Iseni, F., Baudin, F., Garcin, D., Marq, J.B., Ruigrok, R.W., Kolakofsky, D. RNA (2002) [Pubmed]
  6. Paramyxovirus mRNA editing leads to G deletions as well as insertions. Jacques, J.P., Hausmann, S., Kolakofsky, D. EMBO J. (1994) [Pubmed]
  7. Molecular cloning of the 3'-proximal third of Sendai virus genome. Dowling, P.C., Giorgi, C., Roux, L., Dethlefsen, L.A., Galantowicz, M.E., Blumberg, B.M., Kolakofsky, D. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  8. Competition between the Sendai virus N mRNA start site and the genome 3'-end promoter for viral RNA polymerase. Le Mercier, P., Garcin, D., Garcia, E., Kolakofsky, D. J. Virol. (2003) [Pubmed]
  9. A cytoplasmic RNA vector derived from nontransmissible Sendai virus with efficient gene transfer and expression. Li, H.O., Zhu, Y.F., Asakawa, M., Kuma, H., Hirata, T., Ueda, Y., Lee, Y.S., Fukumura, M., Iida, A., Kato, A., Nagai, Y., Hasegawa, M. J. Virol. (2000) [Pubmed]
  10. "Rule of six": how does the Sendai virus RNA polymerase keep count? Vulliémoz, D., Roux, L. J. Virol. (2001) [Pubmed]
  11. Alternative amino acids at a single site in the Sendai virus L protein produce multiple defects in RNA synthesis in vitro. Horikami, S.M., Moyer, S.A. Virology (1995) [Pubmed]
  12. Mutations in conserved domains IV and VI of the large (L) subunit of the sendai virus RNA polymerase give a spectrum of defective RNA synthesis phenotypes. Feller, J.A., Smallwood, S., Horikami, S.M., Moyer, S.A. Virology (2000) [Pubmed]
  13. Molecular cloning and characterization of a Sendai virus internal deletion defective RNA. Engelhorn, M., Stricker, R., Roux, L. J. Gen. Virol. (1993) [Pubmed]
  14. A glycine to alanine substitution in the paramyxovirus SV5 fusion peptide increases the initial rate of fusion. Bagai, S., Lamb, R.A. Virology (1997) [Pubmed]
  15. Functional characterisation of the genomic and antigenomic promoters of Sendai virus. Calain, P., Roux, L. Virology (1995) [Pubmed]
  16. The Sendai virus V protein interacts with the NP protein to regulate viral genome RNA replication. Horikami, S.M., Smallwood, S., Moyer, S.A. Virology (1996) [Pubmed]
 
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