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Gene Review:

Prdx6b - peroxiredoxin 6B

Mus musculus

Synonyms: 1-cysPrx-P1, 4930414C22Rik, Aop2-rs1, Prdx5-rs1, Prdx6-ps1, ...

Mo, Y. et al., Simeone, M. et al.

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High impact information on Prdx6-rs1

In the 1-cysPrx 'knock-out' mouse, 1-cysPrx-P1 mRNA expression level was similar to the wild type but protein expression was not detected [1].
1-cysPrx-P1 mRNA was expressed only in testis [1].
Thus, mouse 1-cysPrx-P1 is an mRNA-expressed pseudogene that does not result in detectable protein in vivo [1].
Mice have a highly related intronless gene (1-cysPrx-P1, GenBank accession number AF085220) with the same length of open reading frame (224 aa) as 1-cysPrx but located on a different chromosome [1].

Other interactions of Prdx6-rs1

We hypothesized that these additional transcripts correspond either to alternative Prdx6 mRNAs or to highly related genes such as the intronless genes Aop2-rs1 and Aop2-rs2 [2].

Analytical, diagnostic and therapeutic context of Prdx6-rs1

Since the product of this gene possibly could mimic 1-cysPrx function, we compared expression of 1-cysPrx and 1-cysPrx-P1 in mouse tissues by real-time polymerase chain reaction and Western blot [1].

References

1-Cys peroxiredoxin knock-out mice express mRNA but not protein for a highly related intronless gene. Mo, Y., Feinstein, S.I., Manevich, Y., Zhang, Q., Lu, L., Ho, Y.S., Fisher, A.B. FEBS Lett. (2003) [Pubmed]
Transcripts associated with Prdx6 (peroxiredoxin 6) and related genes in mouse. Simeone, M., Phelan, S.A. Mamm. Genome (2005) [Pubmed]

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TPX4	Anopheles gambiae str. PEST
Prx2540-2	Drosophila melanogaster
Prx2540-1	Drosophila melanogaster
CG12896	Drosophila melanogaster

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