High impact information on HOXC10

• Among abdominal-B subfamily members, the mitotic proteolysis of HOXC10 appears unique, since the levels of the paralogous HOXD10 and the related homeoprotein HOXC13 are constant throughout the cell cycle [1].
• Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression [1].
• When two destruction box motifs (D-box) are mutated, HOXC10 is stabilized and cells accumulate in metaphase [1].
• Here, we show that HOXC10 oscillates in abundance during the cell cycle, being targeted for degradation early in mitosis by the ubiquitin-dependent proteasome pathway [1].
• We describe the complete open reading frame sequence of HOXC10 and HOXC13 along with the structure of the HoxC13 gene [2].

Biological context of HOXC10

• We also show that HOXC10 expression is cell-type-dependent and positively correlates with cell proliferation [2].
• Double labeling demonstrates that Hoxc10 expression is correlated with ventrolateral LIM gene expression in the caudal part of the lumbar spinal cord [3].

Other interactions of HOXC10

• In addition, the ability of HOXC10 and HOXC13 to increase the activity of a promoter containing the 74 bp sequence, as assayed by CAT-assay experiments, demonstrates a direct interaction of these homeoproteins with the origin sequence in mammalian cells [2].

References