The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Hoxc10  -  homeobox C10

Mus musculus

Synonyms: AI506621, Homeobox protein Hox-3.6, Homeobox protein Hox-C10, Hox-3.6, Hoxc-10
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Hoxc10

  • Alk5 mutant embryos showed malformations in anterior-posterior patterning, including the lack of expression of the posterior determinant Hoxc10, that resemble defects found in Gdf11-null mutants [1].
  • Pitx1 also upregulates hindlimb-specific factors in the forelimb, including Hoxc10 and Tbx4 [2].
  • Novel expression patterns for several genes, such as Pax7, Asb5, IgSF4, and Hoxc10, were identified that were expressed in both quiescent and activated satellite cells [3].
  • Hoxb13 and both transcripts of Hoxc10 are expressed at high levels in the regenerating spinal cord during tail regeneration, and in both regenerating hind limbs and forelimbs [4].
  • We describe here the isolation, structural characterization and spatio-temporal expression pattern of a new AbdB-like homeobox gene designated Hox-3.6 that is located in the 5' region of the Hox-3 cluster [5].

Biological context of Hoxc10

  • Double labeling demonstrates that Hoxc10 expression is correlated with ventrolateral LIM gene expression in the caudal part of the lumbar spinal cord [6].
  • Hox-3.6: isolation and characterization of a new murine homeobox gene located in the 5' region of the Hox-3 cluster [5].
  • Hox-3.6 has an extreme posterior expression domain in embryos of 12.5 days of gestation, a feature that has thus far only been observed for the 5' most genes of the Hox-4 cluster [5].


  1. Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis. Andersson, O., Reissmann, E., Ibáñez, C.F. EMBO Rep. (2006) [Pubmed]
  2. Pitx1 determines the morphology of muscle, tendon, and bones of the hindlimb. Delaurier, A., Schweitzer, R., Logan, M. Dev. Biol. (2006) [Pubmed]
  3. Muscle satellite cell-specific genes identified by genetic profiling of MyoD-deficient myogenic cell. Seale, P., Ishibashi, J., Holterman, C., Rudnicki, M.A. Dev. Biol. (2004) [Pubmed]
  4. Expression of Hoxb13 and Hoxc10 in developing and regenerating Axolotl limbs and tails. Carlson, M.R., Komine, Y., Bryant, S.V., Gardiner, D.M. Dev. Biol. (2001) [Pubmed]
  5. Hox-3.6: isolation and characterization of a new murine homeobox gene located in the 5' region of the Hox-3 cluster. Peterson, R.L., Jacobs, D.F., Awgulewitsch, A. Mech. Dev. (1992) [Pubmed]
  6. Expression patterns of Hox10 paralogous genes during lumbar spinal cord development. Choe, A., Phun, H.Q., Tieu, D.D., Hu, Y.H., Carpenter, E.M. Gene Expr. Patterns (2006) [Pubmed]
WikiGenes - Universities