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Gene Review:

fosB - fosfomycin resistance protein FosB

Staphylococcus epidermidis RP62A

Zilhao, R. et al., Etienne, J. et al.

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Disease relevance of fosB

We have determined the nucleotide sequence of gene fosB of plasmid pIP1842, which confers resistant to fosfomycin in Staphylococcus epidermidis BM2641 [1].
Southern hybridization with a probe specific for gene fosA of Serratia marcescens showed that the fosfomycin resistance determinant in Staphylococcus is not homologous to that of Gram-negative bacteria [2].
The fosB gene product exhibits 48% sequence homology with the fosfomycin resistance protein FOSA of Enterobacteriaceae [1].

High impact information on fosB

Downstream from fosB is located an open reading frame that was partially sequenced [1].

References

Nucleotide sequence of the fosB gene conferring fosfomycin resistance in Staphylococcus epidermidis. Zilhao, R., Courvalin, P. FEMS Microbiol. Lett. (1990) [Pubmed]
Plasmid-mediated resistance to fosfomycin in Staphylococcus epidermidis. Etienne, J., Gerbaud, G., Courvalin, P., Fleurette, J. FEMS Microbiol. Lett. (1989) [Pubmed]

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