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Gene Review:

cyp26b1 - cytochrome P450, family 26, subfamily b,...

Danio rerio

Synonyms: Cyp26B1, Cytochrome P450 26B1, Retinoic acid-metabolizing cytochrome, SO:0000704, fc21d03, ...

Zhao, Q. et al.

Zhao, Dobbs-McAuliffe, Linney,

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High impact information on cyp26b1

The predicted zebrafish cyp26b1 protein shares greater than 73% identity with mammalian homologues. cDNA transfection assays showed that like human cyp26b1, zebrafish cyp26b1 is involved in limiting the activity of retinoic acid [1].

Analytical, diagnostic and therapeutic context of cyp26b1

Reverse transcription-polymerase chain reaction (RT-PCR) analysis of embryonic RNAs suggested that no maternal cyp26b1 message is detectable [1].
Zygotic cyp26b1 message could be detected at 75% epiboly by RT-PCR and localized to presumptive rhombomere 3 and rhombomere 4 at the early two-somite (2S) stage (10.5 hpf: hour post fertilization) by whole mount in situ hybridization [1].

References

Expression of cyp26b1 during zebrafish early development. Zhao, Q., Dobbs-McAuliffe, B., Linney, E. Gene Expr. Patterns (2005) [Pubmed]

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