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Gene Review

Cyp26b1  -  cytochrome P450, family 26, subfamily b,...

Mus musculus

Synonyms: CP26, Cytochrome P450 26B1, Cytochrome P450 retinoic acid-inactivating 2, Cytochrome P450RAI-2, P450RAI-2, ...
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Disease relevance of Cyp26b1

  • CP29 was shown to have activity against gram-negative bacteria that was similar to or better than those of the parent peptides, and CP26 had similar activity [1].

High impact information on Cyp26b1


Anatomical context of Cyp26b1

  • CP29 had cytoplasmic membrane permeabilization activity, as assessed by the unmasking of cytoplasmic beta-galactosidase, similar to that of CEME and its more positively charged derivative named CEMA, whereas CP26 was substantially less effective [1].


  1. Salt-resistant alpha-helical cationic antimicrobial peptides. Friedrich, C., Scott, M.G., Karunaratne, N., Yan, H., Hancock, R.E. Antimicrob. Agents Chemother. (1999) [Pubmed]
  2. Cyp26 genes a1, b1 and c1 are down-regulated in Tbx1 null mice and inhibition of Cyp26 enzyme function produces a phenocopy of DiGeorge Syndrome in the chick. Roberts, C., Ivins, S., Cook, A.C., Baldini, A., Scambler, P.J. Hum. Mol. Genet. (2006) [Pubmed]
  3. Retinoid signaling determines germ cell fate in mice. Bowles, J., Knight, D., Smith, C., Wilhelm, D., Richman, J., Mamiya, S., Yashiro, K., Chawengsaksophak, K., Wilson, M.J., Rossant, J., Hamada, H., Koopman, P. Science (2006) [Pubmed]
  4. Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb. Yashiro, K., Zhao, X., Uehara, M., Yamashita, K., Nishijima, M., Nishino, J., Saijoh, Y., Sakai, Y., Hamada, H. Dev. Cell (2004) [Pubmed]
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