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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CYP26B1  -  cytochrome P450, family 26, subfamily B,...

Homo sapiens

Synonyms: CYP26A2, Cytochrome P450 26A2, Cytochrome P450 26B1, Cytochrome P450 retinoic acid-inactivating 2, Cytochrome P450RAI-2, ...
 
 
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High impact information on CYP26B1

  • Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism [1].
  • We have previously identified two cytochrome P450s, P450RAI-1 and P450RAI-2 (herein named CYP26A1 and CYP26B1), which were shown to be responsible for catabolism of atRA both in the embryo and the adult [2].
  • BACKGROUND: CYP26A1, together with CYP26B1 and CYP26C1, are key enzymes of all-trans retinoic acid (RA) inactivation and their specific and restricted expression in developing embryos participate in the fine tuning RA levels [3].
 

Biological context of CYP26B1

 

Analytical, diagnostic and therapeutic context of CYP26B1

  • In this report, we describe the identification, molecular cloning, and characterization of a second related enzyme, P450RAI-2, which is also involved in the specific inactivation of all-trans-RA [1].

References

  1. Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism. White, J.A., Ramshaw, H., Taimi, M., Stangle, W., Zhang, A., Everingham, S., Creighton, S., Tam, S.P., Jones, G., Petkovich, M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid. Taimi, M., Helvig, C., Wisniewski, J., Ramshaw, H., White, J., Amad, M., Korczak, B., Petkovich, M. J. Biol. Chem. (2004) [Pubmed]
  3. Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida. Rat, E., Billaut-Laden, I., Allorge, D., Lo-Guidice, J.M., Tellier, M., Cauffiez, C., Jonckheere, N., van Seuningen, I., Lhermitte, M., Romano, A., Guéant, J.L., Broly, F. Birth Defects Res. Part A Clin. Mol. Teratol. (2006) [Pubmed]
  4. A second CYP26 P450 in humans and zebrafish: CYP26B1. Nelson, D.R. Arch. Biochem. Biophys. (1999) [Pubmed]
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