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Gene Review

CYP707A3  -  abscisic acid 8'-hydroxylase 3

Arabidopsis thaliana

Synonyms: K9E15.12, K9E15_12, cytochrome P450, family 707, polypeptide 3, ...
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Disease relevance of CYP707A3

  • On dehydration, the cyp707a3-1 mutant accumulated a higher amount of stress-induced ABA than the wild type, an event that occurred relatively later and was coincident with slow drought induction of CYP707A3 [1].

High impact information on CYP707A3

  • Moreover, CYP707A1 and CYP707A3 were also shown to be involved in postgermination growth [2].
  • Conversely, constitutive expression of CYP707A3 relieved growth retardation by ABA, increased transpiration, and a reduction of endogenous ABA in both turgid and dehydrated plants [1].
  • CYP707A3, a major ABA 8'-hydroxylase involved in dehydration and rehydration response in Arabidopsis thaliana [1].
  • The insect cells expressing CYP707A3 efficiently metabolized (+)-ABA to yield phaseic acid, the isomerized form of 8'-hydroxy-ABA [3].
  • For designing a specific inhibitor of this enzyme, the substrate specificity and inhibition of CYP707A3, an ABA 8'-hydroxylase from Arabidopsis thaliana, was investigated using 45 structural analogues of ABA and compared to the structural requirements for ABA activity [4].

Anatomical context of CYP707A3


Associations of CYP707A3 with chemical compounds


Analytical, diagnostic and therapeutic context of CYP707A3


  1. CYP707A3, a major ABA 8'-hydroxylase involved in dehydration and rehydration response in Arabidopsis thaliana. Umezawa, T., Okamoto, M., Kushiro, T., Nambara, E., Oono, Y., Seki, M., Kobayashi, M., Koshiba, T., Kamiya, Y., Shinozaki, K. Plant J. (2006) [Pubmed]
  2. CYP707A1 and CYP707A2, which encode abscisic acid 8'-hydroxylases, are indispensable for proper control of seed dormancy and germination in Arabidopsis. Okamoto, M., Kuwahara, A., Seo, M., Kushiro, T., Asami, T., Hirai, N., Kamiya, Y., Koshiba, T., Nambara, E. Plant Physiol. (2006) [Pubmed]
  3. Arabidopsis CYP707As encode (+)-abscisic acid 8'-hydroxylase, a key enzyme in the oxidative catabolism of abscisic acid. Saito, S., Hirai, N., Matsumoto, C., Ohigashi, H., Ohta, D., Sakata, K., Mizutani, M. Plant Physiol. (2004) [Pubmed]
  4. Differences between the structural requirements for ABA 8'-hydroxylase inhibition and for ABA activity. Ueno, K., Araki, Y., Hirai, N., Saito, S., Mizutani, M., Sakata, K., Todoroki, Y. Bioorg. Med. Chem. (2005) [Pubmed]
  5. A plant growth retardant, Uniconazole, is a potent inhibitor of ABA catabolism in Arabidopsis. Saito, S., Okamoto, M., Shinoda, S., Kushiro, T., Koshiba, T., Kamiya, Y., Hirai, N., Todoroki, Y., Sakata, K., Nambara, E., Mizutani, M. Biosci. Biotechnol. Biochem. (2006) [Pubmed]
  6. Chemical regulation of abscisic acid catabolism in plants by cytochrome P450 inhibitors. Kitahata, N., Saito, S., Miyazawa, Y., Umezawa, T., Shimada, Y., Min, Y.K., Mizutani, M., Hirai, N., Shinozaki, K., Yoshida, S., Asami, T. Bioorg. Med. Chem. (2005) [Pubmed]
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