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Gene Review:

Eo - Ecdysone oxidase

Drosophila melanogaster

Synonyms: CG9504, DmEO, Dmel\CG9504, EObeta1

Takeuchi, H. et al.

Takeuchi, Rigden, Ebrahimi, Turner, Rees,

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High impact information on Eo

DmEO shares only 27% amino acid sequence identity with Spodoptera littoralis (Lepidoptera) EO, yet key substrate-binding residues are well conserved [1].
A model of DmEO is consistent with an inability to catalyse reaction of cholesterol derivatives [1].
When CG9504 was expressed in COS7 cells, significant conversion of ecdysone into 3-dehydroecdysone was observed [1].
By a twin-stranded bioinformatics approach, employing both phylogenomics and model structure-based analysis, we first predicted that DmEO (the EO of Drosophila melanogaster) corresponds to the protein product of gene CG9504 [1].

Analytical, diagnostic and therapeutic context of Eo

Quantitative PCR and enzyme assay showed that DmEO was mainly expressed in the midgut during the late instars at a time corresponding to a hormone titre peak [1].

References

Regulation of ecdysteroid signalling during Drosophila development: identification, characterization and modelling of ecdysone oxidase, an enzyme involved in control of ligand concentration. Takeuchi, H., Rigden, D.J., Ebrahimi, B., Turner, P.C., Rees, H.H. Biochem. J. (2005) [Pubmed]

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