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Chemical Compound Review

KST-1A5291     (2S,5R,9R,10R,13R,17R)-17- [(2S)-3,6...

Synonyms: AR-1A3781, AC1L558C, 39750-00-0, 3-Dehydroecdysone
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Disease relevance of 3-Dehydroecdysone


High impact information on 3-Dehydroecdysone


Biological context of 3-Dehydroecdysone

  • The enzyme responsible for hydroxylation at C-25 of the putative 3-dehydroecdysone precursor, 14-hydroxy-5 beta-cholest-7-en-3,6-dione, is also microsomal, while those mediating hydroxylations at C-22 and C-2 of 3,14,25-trihydroxy-5 beta-cholest-7-en-6-one are mitochondrial [6].
  • The prothoracic glands of the tobacco hornworm, Manduca sexta, respond to prothoracicotropic hormone (PTTH) by a regulatory pathway involving cAMP, protein phosphorylation, protein synthesis, and enhanced secretion of ecdysteroids including ecdysone and 3-dehydroecdysone [7].

Associations of 3-Dehydroecdysone with other chemical compounds


Gene context of 3-Dehydroecdysone


Analytical, diagnostic and therapeutic context of 3-Dehydroecdysone

  • The prothoracic glands (PGs) of Lymantria dispar (day-5 female, last-stage larvae) produce both ecdysone and an ecdysteroid which has the same retention time on reverse-phase liquid chromatography (RPLC) as a known standard of 3-dehydroecdysone [10].


  1. A protein from the cabbage looper, Trichoplusia ni, regulated by a bacterial infection is homologous to 3-dehydroecdysone 3beta-reductase. Lundström, A., Kang, D., Liu, G., Fernandez, C., Warren, J.T., Gilbert, L.I., Steiner, H. Insect Biochem. Mol. Biol. (2002) [Pubmed]
  2. Molecular cloning and characterization of hemolymph 3-dehydroecdysone 3beta-reductase from the cotton leafworm, Spodoptera littoralis. A new member of the third superfamily of oxidoreductases. Chen, J.H., Turner, P.C., Rees, H.H. J. Biol. Chem. (1999) [Pubmed]
  3. Involvement of 3-dehydroecdysone in the 3-epimerization of ecdysone. Milner, N.P., Rees, H.H. Biochem. J. (1985) [Pubmed]
  4. Purification and characterisation of haemolymph 3-dehydroecdysone 3 beta-reductase in relation to ecdysteroid biosynthesis in the cotton leafworm Spodoptera littoralis. Chen, J.H., Webb, T.J., Powls, R., Rees, H.H. Eur. J. Biochem. (1996) [Pubmed]
  5. Action of different ecdysteroids on the regulation of mRNAs for the ecdysone receptor, MHR3, dopa decarboxylase, and a larval cuticle protein in the larval epidermis of the tobacco hornworm, Manduca sexta. Hiruma, K., Böcking, D., Lafont, R., Riddiford, L.M. Gen. Comp. Endocrinol. (1997) [Pubmed]
  6. Early steps in ecdysteroid biosynthesis: evidence for the involvement of cytochrome P-450 enzymes. Grieneisen, M.L., Warren, J.T., Gilbert, L.I. Insect Biochem. Mol. Biol. (1993) [Pubmed]
  7. Regulation and consequences of cellular changes in the prothoracic glands of Manduca sexta during the last larval instar: a review. Smith, W.A. Arch. Insect Biochem. Physiol. (1995) [Pubmed]
  8. Formation of ecdysteroids by Y-organs of the crab, Menippe mercenaria. I. Biosynthesis of 7-dehydrocholesterol in vivo. Rudolph, P.H., Spaziani, E., Wang, W.L. Gen. Comp. Endocrinol. (1992) [Pubmed]
  9. Regulation of ecdysteroid signalling during Drosophila development: identification, characterization and modelling of ecdysone oxidase, an enzyme involved in control of ligand concentration. Takeuchi, H., Rigden, D.J., Ebrahimi, B., Turner, P.C., Rees, H.H. Biochem. J. (2005) [Pubmed]
  10. Conversion of 3-dehydroecdysone by a ketoreductase in post-diapause, pre-hatch eggs of the gypsy moth Lymantria dispar. Kelly, T.J., Thyagaraja, B.S., Bell, R.A., Masler, E.P., Gelman, D.B., Borkovec, A.B. Arch. Insect Biochem. Physiol. (1990) [Pubmed]
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