Gene Review:
ptprna - protein tyrosine phosphatase, receptor...
Danio rerio
Synonyms:
IA-2, SO:0000704, fc43c04, ptprn, wu:fc43c04
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Disease relevance of ptprn
- AIMS/HYPOTHESIS: IA-2 and IA-2beta are major autoantigens in Type I (insulin-dependent) diabetes mellitus and are expressed in neuroendocrine tissues including the brain and pancreatic islets of Langerhans [1].
High impact information on ptprn
- Based on sequence analysis, IA-2 and IA-2beta are transmembrane protein tyrosine phosphatases but lack phosphatase activity because of critical amino acid substitutions in the catalytic domain [1].
- METHODS: IA-2 from various species was identified from EST sequences or cloned from cDNA libraries or both [1].
Associations of ptprn with chemical compounds
- CONCLUSION/INTERPRETATION: Based on these findings and sequence analysis of IA-2 homologs in mammals, we conclude that there is an IA-2 gene family which is a part of the larger protein tyrosine phosphatase superfamily [1].
References
- The IA-2 gene family: homologs in Caenorhabditis elegans, Drosophila and zebrafish. Cai, T., Krause, M.W., Odenwald, W.F., Toyama, R., Notkins, A.L. Diabetologia (2001) [Pubmed]
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