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Gene Review

pdp-1  -  Protein PDP-1

Caenorhabditis elegans

 
 
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Disease relevance of phosphatase

  • Only one isoform of approximately 35 kDa has been isolated from animals, where it is associated with bone resorption and microbial killing through its phosphatase activity, and hydroxyl radical production, respectively [1].
 

High impact information on phosphatase

  • A calcineurin phosphatase antagonizes the KIN-29/MEF-2-regulated pathway to modulate levels of CR gene expression [2].
  • The activities of catalase, superoxide dismutase, isocitrate dehydrogenase, isocitrate lyase, and malate synthase are all higher relative to those in worms that are wild type for these genes, but acid phosphatase is down-regulated and alkaline phosphatase activity is lowered to 10% of the activity measured in age-1(+) and daf-2(+) worms [3].
  • Surprisingly, maturation signals then induce CTD phosphorylation that is associated specifically with transcription initiation steps and accumulates to high levels when expression of the CTD phosphatase FCP-1 is inhibited [4].
  • In the present paper, we identify the pho-1 structural gene, which encodes a histidine acid phosphatase showing highest similarity to human prostatic acid phosphatase [5].
  • The Caenorhabditis elegans mel-11 myosin phosphatase regulatory subunit affects tissue contraction in the somatic gonad and the embryonic epidermis and genetically interacts with the Rac signaling pathway [6].
 

Biological context of phosphatase

  • The localization of the phosphatase responsible for the hydrolysis of the external substrate has been discussed for D. immitis and A. cantonensis based on results of the kinetics and distribution of the enzyme [7].
  • The phosphatase activity of CDC25 drives the cell cycle by removing inhibitory phosphates from cyclin-dependent kinase/cyclin complexes [8].
 

Anatomical context of phosphatase

 

Associations of phosphatase with chemical compounds

  • The present results suggest that there is a significant degree of conservation between O. dentatum and C. elegans in the features and function of the serine/threonine protein phosphatase characterised, which should have implications for detailed investigations into molecular reproductive processes of some parasitic nematodes [11].
  • Alkaline phosphatase and glycyl-L-leucine dipeptidase were significantly depleted, whereas maltase activity was only marginally reduced, and leucine aminopeptidase activity was normal [10].
  • Cholinesterase and phosphatase activities in adults and infective-stage larvae of levamisole-resistant and levamisole-susceptible isolates of Haemonchus contortus [12].
 

Other interactions of phosphatase

References

  1. Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase. Flanagan, J.U., Cassady, A.I., Schenk, G., Guddat, L.W., Hume, D.A. Gene (2006) [Pubmed]
  2. KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC. van der Linden, A.M., Nolan, K.M., Sengupta, P. EMBO J. (2007) [Pubmed]
  3. The gerontogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans. Vanfleteren, J.R., De Vreese, A. FASEB J. (1995) [Pubmed]
  4. Transcription reactivation steps stimulated by oocyte maturation in C. elegans. Walker, A.K., Boag, P.R., Blackwell, T.K. Dev. Biol. (2007) [Pubmed]
  5. Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine. Fukushige, T., Goszczynski, B., Yan, J., McGhee, J.D. Dev. Biol. (2005) [Pubmed]
  6. The Caenorhabditis elegans mel-11 myosin phosphatase regulatory subunit affects tissue contraction in the somatic gonad and the embryonic epidermis and genetically interacts with the Rac signaling pathway. Wissmann, A., Ingles, J., Mains, P.E. Dev. Biol. (1999) [Pubmed]
  7. Acid phosphatase activity demonstrated in the nematodes, Dirofilaria immitis and Angiostrongylus cantonensis with special reference to the characters and distribution. Maki, J., Yanagisawa, T. Parasitology (1980) [Pubmed]
  8. RNA-Mediated interference of a cdc25 homolog in Caenorhabditis elegans results in defects in the embryonic cortical membrane, meiosis, and mitosis. Ashcroft, N.R., Srayko, M., Kosinski, M.E., Mains, P.E., Golden, A. Dev. Biol. (1999) [Pubmed]
  9. Novel regulation of pyruvate dehydrogenase phosphatase activity from mitochondria of the parasitic nematode, Ascaris suum. Song, H., Thissen, J., Komuniecki, R. Mol. Biochem. Parasitol. (1991) [Pubmed]
  10. Intestinal enzyme activity in lambs chronically infected with Trichostrongylus colubriformis: effect of anthelmintic treatment. Jones, D.G. Vet. Parasitol. (1983) [Pubmed]
  11. Molecular characterisation of a male-specific serine/threonine phosphatase from Oesophagostomum dentatum (Nematoda: Strongylida), and functional analysis of homologues in Caenorhabditis elegans. Boag, P.R., Ren, P., Newton, S.E., Gasser, R.B. Int. J. Parasitol. (2003) [Pubmed]
  12. Cholinesterase and phosphatase activities in adults and infective-stage larvae of levamisole-resistant and levamisole-susceptible isolates of Haemonchus contortus. Giménez-Pardo, C., Martínez-Grueiro, M.M., Gómez-Barrio, A., Rodríguez-Caabeiro, F. Vet. Res. Commun. (2003) [Pubmed]
  13. Comparative development of Brugia pahangi and variation in acid hydrolase enzyme titers in. Rodriguez, P.H., Larson, G.A., Lazaro, C.A., Castillon, R., Nasr-Schirf, D. J. Am. Mosq. Control Assoc. (2000) [Pubmed]
 
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