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Gene Review

Tap42  -  Two A-associated protein of 42kDa

Drosophila melanogaster

Synonyms: CG31852, CG6537, Dmel\CG31852, Tap-42/CG31852, dTap42
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High impact information on Tap42

  • These phenotypes are associated with increased accumulation and nuclear localization of PP2A in Tap42 mutant cells [1].
  • In addition, Tap42 is not required for increased cell growth in response to activation of TOR signaling [1].
  • The protein phosphatase 2A (PP2A) regulatory subunit Tap42 is essential for target of rapamycin (TOR)-mediated signaling in yeast, but its role in higher eukaryotes has not been established [1].
  • Instead, we find that Tap42 mutations cause disorganization of spindle microtubules in larval neuroblasts, leading to a preanaphase mitotic arrest in these cells [1].
  • Loss of Tap42 ultimately results in increased JNK signaling, caspase activation, and cell death [1].


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