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Gene Review

Pp1-87B  -  Protein phosphatase 1 at 87B

Drosophila melanogaster

Synonyms: 87B, CG5650, DmPp1-87B, Dmel\CG5650, PP-1alpha, ...
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Disease relevance of Pp1-87B


High impact information on Pp1-87B

  • The structure reveals an extended, rainbow shaped molecule, with tandem helical repeats that bear unexpected resemblance to the armadillo repeats in beta-catenin and the HEAT repeats in protein phosphatase 2A [2].
  • The gene encoding the Drosophila protein phosphatase 2A 55 kd regulatory subunit (PR55) is located at 85F and directs the synthesis of differentially spliced transcripts [3].
  • The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase [3].
  • Therefore, cdc25 is a specific protein phosphatase that dephosphorylates tyrosine and possibly threonine residues on p34cdc2 and regulates MPF activation [4].
  • Germline transformation of mutant flies with the wild-type PP1 87B gene restores normal mitosis, viability, and fertility [5].

Biological context of Pp1-87B

  • Interaction with protein phosphatase 1 Is essential for bifocal function during the morphogenesis of the Drosophila compound eye [6].
  • In contrast, expression of transgenes encoding the Bif F995A mutant, which disrupts binding to PP1, was unable to rescue any aspect of the bif phenotype [6].
  • Metazoans from Drosophila to humans have multiple genes encoding catalytic subunits of PP1 (PP1c), which are involved in a wide range of biological processes [7].
  • Regulatory subunits of PP1 provide the key to understanding the role of PP1, as they are responsible for directing PP1c to different intracellular locations and/or affecting their activity or substrate specificity [7].
  • Drosophila is an excellent model organism in which to characterize the role of PP1 catalytic and regulatory subunits, because it combines molecular and biochemical approaches with powerful genetics, in a well-characterized animal model [7].

Anatomical context of Pp1-87B


Associations of Pp1-87B with chemical compounds


Physical interactions of Pp1-87B


Regulatory relationships of Pp1-87B


Other interactions of Pp1-87B


Analytical, diagnostic and therapeutic context of Pp1-87B


  1. Deficiency of protein phosphatase 2A uncouples the nuclear and centrosome cycles and prevents attachment of microtubules to the kinetochore in Drosophila microtubule star (mts) embryos. Snaith, H.A., Armstrong, C.G., Guo, Y., Kaiser, K., Cohen, P.T. J. Cell. Sci. (1996) [Pubmed]
  2. Structure of Pumilio reveals similarity between RNA and peptide binding motifs. Edwards, T.A., Pyle, S.E., Wharton, R.P., Aggarwal, A.K. Cell (2001) [Pubmed]
  3. The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase. Mayer-Jaekel, R.E., Ohkura, H., Gomes, R., Sunkel, C.E., Baumgartner, S., Hemmings, B.A., Glover, D.M. Cell (1993) [Pubmed]
  4. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Gautier, J., Solomon, M.J., Booher, R.N., Bazan, J.F., Kirschner, M.W. Cell (1991) [Pubmed]
  5. One of the protein phosphatase 1 isoenzymes in Drosophila is essential for mitosis. Axton, J.M., Dombrádi, V., Cohen, P.T., Glover, D.M. Cell (1990) [Pubmed]
  6. Interaction with protein phosphatase 1 Is essential for bifocal function during the morphogenesis of the Drosophila compound eye. Helps, N.R., Cohen, P.T., Bahri, S.M., Chia, W., Babu, K. Mol. Cell. Biol. (2001) [Pubmed]
  7. Yeast Two-Hybrid Screens to Identify Drosophila PP1-Binding Proteins. Bennett, D., Alphey, L. Methods Mol. Biol. (2006) [Pubmed]
  8. Bifocal and PP1 interaction regulates targeting of the R-cell growth cone in Drosophila. Babu, K., Bahri, S., Alphey, L., Chia, W. Dev. Biol. (2005) [Pubmed]
  9. The B' protein phosphatase 2A regulatory subunit well-rounded regulates synaptic growth and cytoskeletal stability at the Drosophila neuromuscular junction. Viquez, N.M., Li, C.R., Wairkar, Y.P., DiAntonio, A. J. Neurosci. (2006) [Pubmed]
  10. Trithorax interacts with type 1 serine/threonine protein phosphatase in Drosophila. Rudenko, A., Bennett, D., Alphey, L. EMBO Rep. (2003) [Pubmed]
  11. Drosophila melanogaster protein phosphatase inhibitor-2: identification of a site important for PP1 inhibition. Helps, N.R., Cohen, P.T. FEBS Lett. (1999) [Pubmed]
  12. Drosophila contains three genes that encode distinct isoforms of protein phosphatase 1. Dombrádi, V., Axton, J.M., Brewis, N.D., da Cruz e Silva, E.F., Alphey, L., Cohen, P.T. Eur. J. Biochem. (1990) [Pubmed]
  13. Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila. Wassarman, D.A., Solomon, N.M., Chang, H.C., Karim, F.D., Therrien, M., Rubin, G.M. Genes Dev. (1996) [Pubmed]
  14. Identification and characterization of a novel protein inhibitor of type 1 protein phosphatase. Shirato, H., Shima, H., Sakashita, G., Nakano, T., Ito, M., Lee, E.Y., Kikuchi, K. Biochemistry (2000) [Pubmed]
  15. The RNA-binding protein Staufen from rat brain interacts with protein phosphatase-1. Monshausen, M., Rehbein, M., Richter, D., Kindler, S. J. Neurochem. (2002) [Pubmed]
  16. The Ca(2+)-calmodulin-activated protein phosphatase calcineurin negatively regulates EGF receptor signaling in Drosophila development. Sullivan, K.M., Rubin, G.M. Genetics (2002) [Pubmed]
  17. Identification of a cDNA encoding a Drosophila calcium/calmodulin regulated protein phosphatase, which has its most abundant expression in the early embryo. Brown, L., Chen, M.X., Cohen, P.T. FEBS Lett. (1994) [Pubmed]
  18. PP1beta9C interacts with Trithorax in Drosophila wing development. Rudenko, A., Bennett, D., Alphey, L. Dev. Dyn. (2004) [Pubmed]
  19. The phosphatase subunit tap42 functions independently of target of rapamycin to regulate cell division and survival in Drosophila. Cygnar, K.D., Gao, X., Pan, D., Neufeld, T.P. Genetics (2005) [Pubmed]
  20. Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A. Hannus, M., Feiguin, F., Heisenberg, C.P., Eaton, S. Development (2002) [Pubmed]
  21. Drosophila PPY, a novel male specific protein serine/threonine phosphatase localised in somatic cells of the testis. Armstrong, C.G., Mann, D.J., Berndt, N., Cohen, P.T. J. Cell. Sci. (1995) [Pubmed]
  22. Protein phosphatase 2A activity affects histone H3 phosphorylation and transcription in Drosophila melanogaster. Nowak, S.J., Pai, C.Y., Corces, V.G. Mol. Cell. Biol. (2003) [Pubmed]
  23. Molecular cloning and developmental expression of the catalytic and 65-kDa regulatory subunits of protein phosphatase 2A in Drosophila. Mayer-Jaekel, R.E., Baumgartner, S., Bilbe, G., Ohkura, H., Glover, D.M., Hemmings, B.A. Mol. Biol. Cell (1992) [Pubmed]
  24. Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2. Mayer-Jaekel, R.E., Ohkura, H., Ferrigno, P., Andjelkovic, N., Shiomi, K., Uemura, T., Glover, D.M., Hemmings, B.A. J. Cell. Sci. (1994) [Pubmed]
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