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Gene Review

Pia4  -  Pristane induced arthritis QTL 4

Rattus norvegicus

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Disease relevance of Pia4


High impact information on Pia4

  • Loci on chromosomes 4 and 6 (Pia2 and Pia3) influence arthritis onset, whereas a locus on chromosome 12 (Pia4) is associated with severity and joint erosion [2].
  • Earlier identified PIA loci were reproduced with high significance; Pia1 (MHC region on chromosome 20), Pia4 (chromosome 12), and Pia7 (chromosome 4) are all major regulators of PIA severity and were also found to operate in concert [3].
  • By using an alternative approach, i.e., linkage analysis using relevant animal models we succeeded in finding the Ncf1 gene residing in the Pia4 quantitative trait locus to be responsible for the severity of pristane induced arthritis in rats [4].
  • In group I (a-d) and III (a-d), CO2 was insufflated 12 h after gastrotomy for 60 min (Pia 4 mmHg) [5].

Physical interactions of Pia4

  • After a two-loci interaction analysis of (E3 x DA)F2 intercross data, Pia3 was found to interact with Pia4 (chromosome 12) [6].


  1. Both common and unique susceptibility genes in different rat strains with pristane-induced arthritis. Lu, S., Nordquist, N., Holmberg, J., Olofsson, P., Pettersson, U., Holmdahl, R. Eur. J. Hum. Genet. (2002) [Pubmed]
  2. Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats. Vingsbo-Lundberg, C., Nordquist, N., Olofsson, P., Sundvall, M., Saxne, T., Pettersson, U., Holmdahl, R. Nat. Genet. (1998) [Pubmed]
  3. Identification and isolation of dominant susceptibility loci for pristane-induced arthritis. Olofsson, P., Holmberg, J., Pettersson, U., Holmdahl, R. J. Immunol. (2003) [Pubmed]
  4. Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice. Hultqvist, M., Holmdahl, R. Cell. Immunol. (2005) [Pubmed]
  5. A pneumoperitoneum perpetuates severe damage to the ultrastructural integrity of parietal peritoneum in gastric perforation-induced peritonitis in rats. Bloechle, C., Kluth, D., Holstein, A.F., Emmermann, A., Strate, T., Zornig, C., Izbicki, J.R. Surgical endoscopy. (1999) [Pubmed]
  6. Two-loci interaction confirms arthritis-regulating quantitative trait locus on rat chromosome 6. Olofsson, P., Wernhoff, P., Holmberg, J., Holmdahl, R. Genomics (2003) [Pubmed]
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