Gene Review:
Ncf1 - neutrophil cytosolic factor 1
Mus musculus
Synonyms:
47 kDa neutrophil oxidase factor, NADPH oxidase subunit (47kDa), NCF-1, NCF-47K, NOXO2, ...
- Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Hultqvist, M., Olofsson, P., Holmberg, J., Bäckström, B.T., Tordsson, J., Holmdahl, R. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Bb2Bb3 regulation of murine Lyme arthritis is distinct from Ncf1 and independent of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase. Crandall, H., Ma, Y., Dunn, D.M., Sundsbak, R.S., Zachary, J.F., Olofsson, P., Holmdahl, R., Weis, J.H., Weiss, R.B., Teuscher, C., Weis, J.J. Am. J. Pathol. (2005)
- Genomic organization of the genes Gtf2ird1, Gtf2i, and Ncf1 at the mouse chromosome 5 region syntenic to the human chromosome 7q11.23 Williams syndrome critical region. Bayarsaihan, D., Dunai, J., Greally, J.M., Kawasaki, K., Sumiyama, K., Enkhmandakh, B., Shimizu, N., Ruddle, F.H. Genomics (2002)
- Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models. van de Loo, F.A., Bennink, M.B., Arntz, O.J., Smeets, R.L., Lubberts, E., Joosten, L.A., van Lent, P.L., Coenen-de Roo, C.J., Cuzzocrea, S., Segal, B.H., Holland, S.M., van den Berg, W.B. Am. J. Pathol. (2003)
- Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide. Krieglstein, C.F., Cerwinka, W.H., Laroux, F.S., Salter, J.W., Russell, J.M., Schuermann, G., Grisham, M.B., Ross, C.R., Granger, D.N. J. Exp. Med. (2001)
- The p47phox mouse knock-out model of chronic granulomatous disease. Jackson, S.H., Gallin, J.I., Holland, S.M. J. Exp. Med. (1995)
- NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. Bataller, R., Schwabe, R.F., Choi, Y.H., Yang, L., Paik, Y.H., Lindquist, J., Qian, T., Schoonhoven, R., Hagedorn, C.H., Lemasters, J.J., Brenner, D.A. J. Clin. Invest. (2003)
- The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Kanai, F., Liu, H., Field, S.J., Akbary, H., Matsuo, T., Brown, G.E., Cantley, L.C., Yaffe, M.B. Nat. Cell Biol. (2001)
- Impaired pulmonary NF-kappaB activation in response to lipopolysaccharide in NADPH oxidase-deficient mice. Koay, M.A., Christman, J.W., Segal, B.H., Venkatakrishnan, A., Blackwell, T.R., Holland, S.M., Blackwell, T.S. Infect. Immun. (2001)
- Suppression of Plasmodium chabaudi parasitemia is independent of the action of reactive oxygen intermediates and/or nitric oxide. Gillman, B.M., Batchelder, J., Flaherty, P., Weidanz, W.P. Infect. Immun. (2004)
- Effect of amphotericin B and micafungin combination on survival, histopathology, and fungal burden in experimental aspergillosis in the p47phox-/- mouse model of chronic granulomatous disease. Dennis, C.G., Greco, W.R., Brun, Y., Youn, R., Slocum, H.K., Bernacki, R.J., Lewis, R., Wiederhold, N., Holland, S.M., Petraitiene, R., Walsh, T.J., Segal, B.H. Antimicrob. Agents Chemother. (2006)
- Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. Geiszt, M., Lekstrom, K., Witta, J., Leto, T.L. J. Biol. Chem. (2003)
- Control of plasma glucose with alpha-glucosidase inhibitor attenuates oxidative stress and slows the progression of heart failure in mice. Liao, Y., Takashima, S., Zhao, H., Asano, Y., Shintani, Y., Minamino, T., Kim, J., Fujita, M., Hori, M., Kitakaze, M. Cardiovasc. Res. (2006)
- Angiotensin II induces MMP-2 in a p47phox-dependent manner. Luchtefeld, M., Grote, K., Grothusen, C., Bley, S., Bandlow, N., Selle, T., Strüber, M., Haverich, A., Bavendiek, U., Drexler, H., Schieffer, B. Biochem. Biophys. Res. Commun. (2005)
- Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: a possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone. Keidar, S., Kaplan, M., Pavlotzky, E., Coleman, R., Hayek, T., Hamoud, S., Aviram, M. Circulation (2004)
- Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase. Sorescu, G.P., Song, H., Tressel, S.L., Hwang, J., Dikalov, S., Smith, D.A., Boyd, N.L., Platt, M.O., Lassègue, B., Griendling, K.K., Jo, H. Circ. Res. (2004)
- AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase. Dechend, R., Viedt, C., Müller, D.N., Ugele, B., Brandes, R.P., Wallukat, G., Park, J.K., Janke, J., Barta, P., Theuer, J., Fiebeler, A., Homuth, V., Dietz, R., Haller, H., Kreuzer, J., Luft, F.C. Circulation (2003)
- Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis. Reinehr, R., Becker, S., Eberle, A., Grether-Beck, S., Häussinger, D. J. Biol. Chem. (2005)
- Involvement of several protein kinases in the phosphorylation of p47-phox. Yamaguchi, M., Saeki, S., Yamane, H., Okamura, N., Ishibashi, S. Biochem. Biophys. Res. Commun. (1996)
- Both inducible nitric oxide synthase and NADPH oxidase contribute to the control of virulent phase I Coxiella burnetii infections. Brennan, R.E., Russell, K., Zhang, G., Samuel, J.E. Infect. Immun. (2004)
- p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia. Sadikot, R.T., Zeng, H., Yull, F.E., Li, B., Cheng, D.S., Kernodle, D.S., Jansen, E.D., Contag, C.H., Segal, B.H., Holland, S.M., Blackwell, T.S., Christman, J.W. J. Immunol. (2004)
- p47phox-dependent NADPH oxidase regulates flow-induced vascular remodeling. Castier, Y., Brandes, R.P., Leseche, G., Tedgui, A., Lehoux, S. Circ. Res. (2005)
- Genetics of autoimmune diseases: a multistep process. Johannesson, M., Hultqvist, M., Holmdahl, R. Curr. Top. Microbiol. Immunol. (2006)
- Endothelial NADPH oxidase as the source of oxidants in lungs exposed to ischemia or high K+. Al-Mehdi, A.B., Zhao, G., Dodia, C., Tozawa, K., Costa, K., Muzykantov, V., Ross, C., Blecha, F., Dinauer, M., Fisher, A.B. Circ. Res. (1998)
- Cdc42 regulates arsenic-induced NADPH oxidase activation and cell migration through actin filament reorganization. Qian, Y., Liu, K.J., Chen, Y., Flynn, D.C., Castranova, V., Shi, X. J. Biol. Chem. (2005)
- Repressor activity of CCAAT displacement protein in HL-60 myeloid leukemia cells. Lievens, P.M., Donady, J.J., Tufarelli, C., Neufeld, E.J. J. Biol. Chem. (1995)