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Gene Review

Cia7  -  Collagen induced arthritis QTL 7

Rattus norvegicus

 
 
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Disease relevance of Cia7

 

High impact information on Cia7

  • Cia26 is in epistasis with Cia7 and regulates later stages of disease, suggesting an involvement in disease perpetuation and/or chronicity [2].
  • All 327 rats were genotyped with the simple sequence-length polymorphism (SSLP) markers closest to the peak of Cia7 and Cia10, the major loci previously identified in this intercross, and with SSLPs covering chromosomes 12 and 18 [2].
  • A 2-locus interaction model analysis identified a novel recessive chromosome 18 QTL, Cia26, which was dependent on Cia7, with its maximum effect observed at later stages during the disease course (peak LOD score of 3.6 for arthritis scores on day 39) [2].
  • CONCLUSION: Sex chromosomes and Cia7 play an important role in regulating CIA in response to RII [1].
 

Biological context of Cia7

  • In addition, a major QTL was localized on chromosome 2 (Cia7, logarithm of odds score 4.6) [1].

References

  1. Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats. Gulko, P.S., Kawahito, Y., Remmers, E.F., Reese, V.R., Wang, J., Dracheva, S.V., Ge, L., Longman, R.E., Shepard, J.S., Cannon, G.W., Sawitzke, A.D., Wilder, R.L., Griffiths, M.M. Arthritis Rheum. (1998) [Pubmed]
  2. Identification of two novel female-specific non-major histocompatibility complex loci regulating collagen-induced arthritis severity and chronicity, and evidence of epistasis. Meng, H.C., Griffiths, M.M., Remmers, E.F., Kawahito, Y., Li, W., Neisa, R., Cannon, G.W., Wilder, R.L., Gulko, P.S. Arthritis Rheum. (2004) [Pubmed]
 
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