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Gene Review

Axs  -  Abnormal X segregation

Drosophila melanogaster

Synonyms: CG9703, Dmel\CG9703, axs
 
 
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High impact information on Axs

  • Mutations in the aberrant X segragation (Axs) gene disrupt the segregation of achiasmate chromosomes during female meiosis in Drosophila melanogaster [1].
  • Axs protein colocalizes with components of the endoplasmic reticulum and is present within a structure ensheathing the meiotic spindle [1].
  • In both meiotic and mitotic cells, Axs is recruited to the microtubules of assembling spindles [1].
  • We also characterize the interactions of mutations at the Axs locus with two other meiotic mutations (ald and ncd) [2].
  • The effect of Axs on these segregations parallels the defects observed for homologous nonexchange X chromosome disjunction in Axs females [3].
 

Biological context of Axs

  • In the absence of Axs+ function, the homologs are often unable to separate from each other and behave as a single segregational unit that is free to segregate from heterologous chromosomes [2].
  • This increased X chromosome nondisjunction is shown to be a consequence of an Axs-induced defect in distributive segregation [3].
  • In addition, Axs diminishes or ablates the capacity of nonexchange X chromosomes to form trivalents in females bearing either a Y chromosome or a small free duplication for the X. Axs also impairs compound X from Y segregation [3].
  • The meiotic mutation Axs differentiates between these two processes of achiasmate centromere coorientation by disrupting only the homology-dependent mechanism [4].
  • Axs mutations disrupt both the progression of the meiotic cell cycle and meiotic chromosome segregation in Drosophila [5].

References

 
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