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Gene Review: 

RhoGAPp190  -  Rho GTPase activating protein p190

Drosophila melanogaster

Synonyms: 8267, BcDNA:GH17919, BcDNA:GM05133, CG32555, CG8240, ...
 
 
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High impact information on RhoGAPp190

  • Central spindle assembly is mediated by a microtubule-associated protein and a kinesin-RhoGAP complex, both of which are regulated by phosphorylation/dephosphorylation [1].
  • The RhoGAP crossveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invagination [2].
  • The corresponding cDNA encodes a predicted 30 kDa subunit containing a Ras homologous GTPase Activating Protein (RhoGAP) domain, suggesting a possible involvement in the regulation of actin cytoskeleton changes [3].
  • The implication of the P4 protein in suppressing the host cellular immunity is discussed in correlation with its predicted molecular function as a Rho-GAP protein [4].

References

  1. Cytokinesis: progress on all fronts. Glotzer, M. Curr. Opin. Cell Biol. (2003) [Pubmed]
  2. The RhoGAP crossveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invagination. Brodu, V., Casanova, J. Genes Dev. (2006) [Pubmed]
  3. A RhoGAP protein as a main immune suppressive factor in the Leptopilina boulardi (Hymenoptera, Figitidae)-Drosophila melanogaster interaction. Labrosse, C., Stasiak, K., Lesobre, J., Grangeia, A., Huguet, E., Drezen, J.M., Poirie, M. Insect Biochem. Mol. Biol. (2005) [Pubmed]
  4. Haemocyte changes in D. Melanogaster in response to long gland components of the parasitoid wasp Leptopilina boulardi: a Rho-GAP protein as an important factor. Labrosse, C., Eslin, P., Doury, G., Drezen, J.M., Poirié, M. J. Insect Physiol. (2005) [Pubmed]
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