Gene Review:
Arhgap35 - Rho GTPase activating protein 35
Mus musculus
Synonyms:
6430596G11Rik, AI841135, Glucocorticoid receptor DNA-binding factor 1, Grlf1, Grlf1,Kiaa1722, ...
- p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation. Brouns, M.R., Matheson, S.F., Settleman, J. Nat. Cell Biol. (2001)
- Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis. Kusama, T., Mukai, M., Endo, H., Ishikawa, O., Tatsuta, M., Nakamura, H., Inoue, M. Cancer Sci. (2006)
- Protein tyrosine phosphatase receptor type Z is involved in hippocampus-dependent memory formation through dephosphorylation at Y1105 on p190 RhoGAP. Tamura, H., Fukada, M., Fujikawa, A., Noda, M. Neurosci. Lett. (2006)
- Phosphotyrosine (p-Tyr)-dependent and -independent mechanisms of p190 RhoGAP-p120 RasGAP interaction: Tyr 1105 of p190, a substrate for c-Src, is the sole p-Tyr mediator of complex formation. Roof, R.W., Haskell, M.D., Dukes, B.D., Sherman, N., Kinter, M., Parsons, S.J. Mol. Cell. Biol. (1998)
- Ras-GAP controls Rho-mediated cytoskeletal reorganization through its SH3 domain. Leblanc, V., Tocque, B., Delumeau, I. Mol. Cell. Biol. (1998)
- The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development. Brouns, M.R., Matheson, S.F., Hu, K.Q., Delalle, I., Caviness, V.S., Silver, J., Bronson, R.T., Settleman, J. Development (2000)
- Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap. van der Geer, P., Henkemeyer, M., Jacks, T., Pawson, T. Mol. Cell. Biol. (1997)
- p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling. Barberis, D., Casazza, A., Sordella, R., Corso, S., Artigiani, S., Settleman, J., Comoglio, P.M., Tamagnone, L. J. Cell. Sci. (2005)
- Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity. Chen, J.C., Zhuang, S., Nguyen, T.H., Boss, G.R., Pilz, R.B. J. Biol. Chem. (2003)
- Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity. Barker, T.H., Grenett, H.E., MacEwen, M.W., Tilden, S.G., Fuller, G.M., Settleman, J., Woods, A., Murphy-Ullrich, J., Hagood, J.S. Exp. Cell Res. (2004)
- Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. Wennerberg, K., Forget, M.A., Ellerbroek, S.M., Arthur, W.T., Burridge, K., Settleman, J., Der, C.J., Hansen, S.H. Curr. Biol. (2003)