Gene Review:
ASAP1 - ArfGAP with SH3 domain, ankyrin repeat and...
Bos taurus
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High impact information on DDEF1
- Ectopic expression of DEF-1 in fibroblasts resulted in the differentiation of a significant fraction of the culture into adipocytes [1].
- Further evidence for a role for DEF-1 in adipogenesis was provided by heightened expression of DEF-1 mRNA in adipose tissue isolated from obese and diabetes mice compared to that in tissue isolated from wild-type mice [1].
- These results suggest that DEF-1 is an important component of a signal transduction process that is involved in the differentiation of fibroblasts and possibly of other types of cells [1].
- This phenotype appears to be related to the induction of the transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma), since DEF-1 NIH 3T3 cells demonstrated augmented levels of PPARgamma mRNA and, when treated with activating PPARgamma ligands, efficient induction of differentiation [1].
References
- DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines. King, F.J., Hu, E., Harris, D.F., Sarraf, P., Spiegelman, B.M., Roberts, T.M. Mol. Cell. Biol. (1999) [Pubmed]
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