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Gene Review

por  -  porcupine

Drosophila melanogaster

Synonyms: 15175, CG6205, Dmel\CG6205, Porc, Protein-cysteine N-palmitoyltransferase porcupine, ...
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High impact information on por

  • Lack of porcupine (porc) activity is associated with mutant phenotypes similar to those of wg mutations [1].
  • While the activities of dsh, zw3 and arm appear to be specific to the paracrine feedback pathway, the more direct autoregulatory pathway requires porc [2].
  • Lipidation occurs in the endoplasmic reticulum and is dependent on Porcupine, a putative O-acyltransferase [3].
  • Porc is also necessary for the processing of Drosophila Wnt-3/5 in both embryos and cultured cells [4].
  • Thus, Porc binds the N-terminal specific domain of the Wnt family and stimulates its posttranslational N-glycosylation by anchoring them at the ER membrane possibly through acylation [4].

Regulatory relationships of por

  • In contrast, the ectopic expression of porc stimulates the N-glycosylation of both endogenously and exogenously expressed Wg [4].

Analytical, diagnostic and therapeutic context of por


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