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Gene Review:

Dleu2 - deleted in lymphocytic leukemia, 2

Mus musculus

This record was replaced with 668253.

Szirtes, T. et al., Yoon, S.H. et al., Zamoyska, R. et al.

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High impact information on Dleu2

By transfection we have shown that the mouse homologue of Leu-2/T8 is Lyt-2 and not Lyt-3 [1].
Replacement of pyroglutamic acid by pyro-2-aminoadipic acid, 2-oxoimidazolidine-4-carboxylic acid or gamma-butyrolactone-gamma-carboxylic acid and that of proline by pipecolic acid, thiazolidine-4-carboxylic acid, or homoproline in [Leu2]- and [Nva2]TRH led to tripeptides structurally widely different from TRH [2].
A chemical targeting system for [Leu2, Pip3]-TRH (Gln,Leu,Pip) was synthesized in order to allow its specific delivery to the central nervous system (CNS) [3].

References

Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA. Zamoyska, R., Vollmer, A.C., Sizer, K.C., Liaw, C.W., Parnes, J.R. Cell (1985) [Pubmed]
Synthesis of thyrotropin-releasing hormone analogues. 2. Tripeptides structurally greatly differing from TRH with high central nervous system activity. Szirtes, T., Kisfaludy, L., Pálosi, E., Szporny, L. J. Med. Chem. (1986) [Pubmed]
Brain-targeted chemical delivery of [Leu2, Pip3]-TRH: synthesis and biological evaluation. Yoon, S.H., Wu, J., Wu, W.M., Prokai, L., Bodor, N. Bioorg. Med. Chem. (2000) [Pubmed]

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