Gene Review:
Cd8a - CD8 antigen, alpha chain
Mus musculus
Synonyms:
BB154331, Ly-2, Ly-35, Ly-B, Lyt-2, ...
- Genetic control of resistance to 3-methylcholanthrene-induced T-cell lymphoma in mice. Ishizaka, S.T., Lilly, F. Cancer Res. (1989)
- Quantitative immunofluorescent analysis of surface phenotypes of murine B cell lymphomas and plasmacytomas with monoclonal antibodies. Lanier, L.L., Warner, N.L., Ledbetter, J.A., Herzenberg, L.A. J. Immunol. (1981)
- Activation of Lyt-2 associated with distant upstream insertion of an SL3-3 provirus. Anson, D.S., Clarkin, K., Hyman, R. Immunogenetics (1992)
- Functionally involved cell surface antigens on murine lymphokine activated killer cells. Belfrage, H., Bhiladvala, P., Kalland, T. Immunol. Lett. (1987)
- Experimental systemic amyloidosis induced by immunization with syngeneic organ extracts in mice. Mori, Y., Akikusa, B., Mori, T., Ueda, S., Iesato, K., Yoshida, H., Ogawa, M., Kato, I., Wakashin, Y., Wakashin, M. J. Exp. Med. (1986)
- CD8 is needed for development of cytotoxic T cells but not helper T cells. Fung-Leung, W.P., Schilham, M.W., Rahemtulla, A., Kündig, T.M., Vollenweider, M., Potter, J., van Ewijk, W., Mak, T.W. Cell (1991)
- Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes. Gabert, J., Langlet, C., Zamoyska, R., Parnes, J.R., Schmitt-Verhulst, A.M., Malissen, B. Cell (1987)
- Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA. Zamoyska, R., Vollmer, A.C., Sizer, K.C., Liaw, C.W., Parnes, J.R. Cell (1985)
- Regulatory effect of lymphokine-activated killer cells on epidermal proliferation induced by cholera toxin in mice. Okamoto, Y., Tanaka, N., Orita, K. Acta Med. Okayama (1994)
- Induction of tumor suppression and delayed-type footpad reaction by transfer of lymphocytes sensitized to a xenogenized tumor variant. Bianchi, R., Romani, L., Puccetti, P., Fioretti, M.C. Int. J. Cancer (1988)
- Formal proof that different-size Lyt-2 polypeptides arise from differential splicing and post-transcriptional regulation. Tagawa, M., Nakauchi, H., Herzenberg, L.A., Nolan, G.P. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Interleukin 2 production by lymphoid cells from congenitally athymic (nu/nu) mice. MacDonald, H.R., Lees, R.K., Glasebrook, A.L., Sordat, B. J. Immunol. (1982)
- The major histocompatibility complex-restricted antigen receptor on T cells: the genetics of expression of an allotype. Roehm, N.W., Carbone, A., Kushnir, E., Taylor, B.A., Riblet, R.J., Marrack, P., Kappler, J.W. J. Immunol. (1985)
- Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development. Feik, N., Bilic, I., Tinhofer, J., Unger, B., Littman, D.R., Ellmeier, W. J. Immunol. (2005)
- Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells. Ceredig, R., Lowenthal, J.W., Nabholz, M., MacDonald, H.R. Nature (1985)
- CD4 and CD8 regulate interleukin 2 responses of T cells. Takahashi, K., Nakata, M., Tanaka, T., Adachi, H., Nakauchi, H., Yagita, H., Okumura, K. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Cloned natural suppressor cell lines derived from the spleens of neonatal mice. Schwadron, R.B., Gandour, D.M., Strober, S. J. Exp. Med. (1985)
- Surface mapping of mouse thymocytes. Flaherty, L., Zimmerman, D. Proc. Natl. Acad. Sci. U.S.A. (1979)
- In vitro induction of CD8 expression on thymic pre-T cells. II. Characterization of CD3-CD4-CD8 alpha + cells generated in vitro by culturing CD25+CD3-CD4-CD8- thymocytes with T cell growth factor-beta and tumor necrosis factor-alpha. Suda, T., Zlotnik, A. J. Immunol. (1992)
- Cytotoxic mechanisms of murine lymphokine-activated killer cells: functional and biochemical characterization of homogeneous populations of spleen LAK cells. Zychlinsky, A., Joag, S., Liu, C.C., Young, J.D. Cell. Immunol. (1990)
- Role of L3T4 in antigen-driven activation of a class I-specific T cell hybridoma. Greenstein, J.L., Malissen, B., Burakoff, S.J. J. Exp. Med. (1985)
- Interactions between molecules (subfactors) released by different T cell sets that yield a complete factor with biological (suppressive) activity. Ptak, W., Rosenstein, R.W., Gershon, R.K. Proc. Natl. Acad. Sci. U.S.A. (1982)
- In vitro induction of CD8 expression on thymic pre-T cells. I. Transforming growth factor-beta and tumor necrosis factor-alpha induce CD8 expression on CD8- thymic subsets including the CD25+CD3-CD4-CD8- pre-T cell subset. Suda, T., Zlotnik, A. J. Immunol. (1992)
- Differential susceptibility of mouse Lyt-2 and Lyt-3 genes to negative regulation. Hwang, I., Gu, J.J., Gottlieb, P.D. Immunogenetics (1993)
- Monoclonal antibody to Lyt 2 antigen blocks H-2I- and H-2K- specific mouse cytotoxic T cells. Miller, R.A., Stutman, O. Nature (1982)
- Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. I. Requirement of Lyt-1 dull L3T4 bright normal T cells for the induction of thyroiditis. Sugihara, S., Izumi, Y., Yoshioka, T., Yagi, H., Tsujimura, T., Tarutani, O., Kohno, Y., Murakami, S., Hamaoka, T., Fujiwara, H. J. Immunol. (1988)
- Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expression. Gorman, S.D., Sun, Y.H., Zamoyska, R., Parnes, J.R. J. Immunol. (1988)
- Genetic control of the humoral response to an H-2 public specificity. Hansen, T.H., Cullen, S.E., Shinohara, N., Schurko, E., Sachs, D.H. J. Immunol. (1977)
- gamma-Glutamyl cyclotransferase: a new genetic polymorphism in the mouse (Mus musculus) linked to Lyt-2. Tulchin, N., Taylor, B.A. Genetics (1981)
- Linkage of the murine transforming growth factor alpha gene with Igk, Ly-2, and Fabp1 on chromosome 6. Fowler, K.J., Mann, G.B., Dunn, A.R. Genomics (1993)
- Mapping of Igk-V genes using backcrossed laboratory and wild mice. Rueff-Juy, D., Drapier, A.M., Cazenave, P.A. Immunogenetics (1988)
- Recombinant interleukin 4/BSF-1 promotes growth and differentiation of intrathymic T cell precursors from fetal mice in vitro. Palacios, R., Sideras, P., von Boehmer, H. EMBO J. (1987)
- Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to its human counterpart, Leu-2/T8, and to immunoglobulin variable regions. Nakauchi, H., Nolan, G.P., Hsu, C., Huang, H.S., Kavathas, P., Herzenberg, L.A. Proc. Natl. Acad. Sci. U.S.A. (1985)
- Proliferation in vitro and interleukin production by 14 day fetal and adult Lyt-2-/L3T4- mouse thymocytes. Ceredig, R. J. Immunol. (1986)
- Interleukin-2 and coculture with thymic epithelial cells synergistically induce prothymocyte differentiation and proliferation. Wiranowska, M., Kaido, T., Caspritz, G., Cook, J., Hadden, J. Thymus (1987)