Chemical Compound Review:
Pyroglutamate 5-oxopyrrolidine-2-carboxylic acid
Synonyms:
PubChem9493, SureCN15791, CHEMBL284718, AG-D-96299, Proline,5-oxo-, ...
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- Initiation by methionine of mouse immunoglobulin light chain containing NH-2terminal pyroglutamic acid. Prasad, C., Peterkofsky, A. J. Biol. Chem. (1975)
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- Generation of amyloid beta peptide with pyroglutamate at position 3 in primary cortical neurons. Shirotani, K., Tsubuki, S., Lee, H.J., Maruyama, K., Saido, T.C. Neurosci. Lett. (2002)
- Striatal deficiency of L-pyroglutamic acid in Huntington's disease is accompanied by increased plasma levels. Uhlhaas, S., Lange, H. Brain Res. (1988)
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- Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation. Huang, K.F., Liu, Y.L., Cheng, W.J., Ko, T.P., Wang, A.H. Proc. Natl. Acad. Sci. U.S.A. (2005)
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- Excessive excretion of 5-oxoproline and decreased levels of blood glutathione in type II diabetes mellitus. Forrester, T.E., Badaloo, V., Bennett, F.I., Jackson, A.A. European journal of clinical nutrition. (1990)
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- Resolution of 5-oxo-L-prolinase into a 5-oxo-L-proline-dependent ATPase and a coupling protein. Seddon, A.P., Li, L.Y., Meister, A. J. Biol. Chem. (1984)
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- Post-translational modification of bovine pro-opiomelanocortin. Tyrosine sulfation and pyroglutamate formation, a mass spectrometric study. Bateman, A., Solomon, S., Bennett, H.P. J. Biol. Chem. (1990)
- In vitro digestion of gliadin by gastrointestinal enzymes and by pyrrolidonecarboxylate peptidase. Caldwell, K.A. Am. J. Clin. Nutr. (1980)
- Pyroglutamate-modified amyloid beta-peptides--AbetaN3(pE)--strongly affect cultured neuron and astrocyte survival. Russo, C., Violani, E., Salis, S., Venezia, V., Dolcini, V., Damonte, G., Benatti, U., D'Arrigo, C., Patrone, E., Carlo, P., Schettini, G. J. Neurochem. (2002)
- Formation of N-pyroglutamyl peptides from N-Glu and N-Gln precursors in Aplysia neurons. Garden, R.W., Moroz, T.P., Gleeson, J.M., Floyd, P.D., Li, L., Rubakhin, S.S., Sweedler, J.V. J. Neurochem. (1999)
- Toxicity of pyroglutaminated amyloid beta-peptides 3(pE)-40 and -42 is similar to that of A beta1-40 and -42. Tekirian, T.L., Yang, A.Y., Glabe, C., Geddes, J.W. J. Neurochem. (1999)
- Partial amino-acid sequence of the precursor of an immunoglobulin light chain containing NH2-terminal pyroglutamic acid. Burstein, Y., Kantour, F., Schechter, I. Proc. Natl. Acad. Sci. U.S.A. (1976)
- Characterization of a pyroglutamate aminopeptidase from rat serum that degrades thyrotropin-releasing hormone. Taylor, W.L., Dixon, J.E. J. Biol. Chem. (1978)
- Functional annotation of two orphan G-protein-coupled receptors, Drostar1 and -2, from Drosophila melanogaster and their ligands by reverse pharmacology. Kreienkamp, H.J., Larusson, H.J., Witte, I., Roeder, T., Birgul, N., Honck, H.H., Harder, S., Ellinghausen, G., Buck, F., Richter, D. J. Biol. Chem. (2002)
- 5-Oxo-L-prolinase (L-pyroglutamate hydrolase). Purification and catalytic properties. Van Der Werf, P., Griffith, O.W., Meister, A. J. Biol. Chem. (1975)
- Primary structure of human plasma fibronectin. The 29,000-dalton NH2-terminal domain. Garcia-Pardo, A., Pearlstein, E., Frangione, B. J. Biol. Chem. (1983)
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- Identification of residues of the epidermal growth factor receptor proximal to residue 45 of bound epidermal growth factor. Summerfield, A.E., Hudnall, A.K., Lukas, T.J., Guyer, C.A., Staros, J.V. J. Biol. Chem. (1996)
- Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors. Blaszczyk, J., Coillie, E.V., Proost, P., Damme, J.V., Opdenakker, G., Bujacz, G.D., Wang, J.M., Ji, X. Biochemistry (2000)
- Amyloid beta-protein (Abeta) 1-40 but not Abeta1-42 contributes to the experimental formation of Alzheimer disease amyloid fibrils in rat brain. Shin, R.W., Ogino, K., Kondo, A., Saido, T.C., Trojanowski, J.Q., Kitamoto, T., Tateishi, J. J. Neurosci. (1997)
- Human seminal relaxin is a product of the same gene as human luteal relaxin. Winslow, J.W., Shih, A., Bourell, J.H., Weiss, G., Reed, B., Stults, J.T., Goldsmith, L.T. Endocrinology (1992)
- The primary structure of aphrodisin. Henzel, W.J., Rodriguez, H., Singer, A.G., Stults, J.T., Macrides, F., Agosta, W.C., Niall, H. J. Biol. Chem. (1988)
- Post-translational processing of preprosomatostatin-II examined using fast atom bombardment mass spectrometry. Andrews, P.C., Nichols, R., Dixon, J.E. J. Biol. Chem. (1987)
- Interaction of the protein components of 5-oxoprolinase. Substrate-dependent enzyme complex formation. Li, L.Y., Seddon, A.P., Meister, A. J. Biol. Chem. (1988)
- Complete amino acid sequence determinations demonstrate identity of the urinary Bence Jones protein (BJP-DIA) and the amyloid fibril protein (AL-DIA) in a case of AL-amyloidosis. Klafki, H.W., Kratzin, H.D., Pick, A.I., Eckart, K., Karas, M., Hilschmann, N. Biochemistry (1992)
- Strain-based sequence variations and structure analysis of murine prostate specific spermine binding protein using mass spectrometry. Chaurand, P., DaGue, B.B., Ma, S., Kasper, S., Caprioli, R.M. Biochemistry (2001)