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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HSPA1B  -  heat shock 70kDa protein 1B

Homo sapiens

Synonyms: HSP70-1B, HSP70-2
 
 
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High impact information on HSPA1B

  • Patients carrying the genotypes HSPA1B AG or HSPA1L CT had significantly higher plasma concentrations of tumor necrosis factor-alpha and interleukin-6 compared with those with genotype GG or TT [1].
  • Allele frequency of the HSPA1B 1538 G allele was 0.569, and that of the HSPA1L 2437 T allele was 0.821 [1].
  • Two copies of the Hsp70 gene, HSPA1A and HSPA1B, are located on chromosome 6p21 [2].
 

Biological context of HSPA1B

  • Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury [1].
 

Analytical, diagnostic and therapeutic context of HSPA1B

References

  1. Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury. Schröder, O., Schulte, K.M., Ostermann, P., Röher, H.D., Ekkernkamp, A., Laun, R.A. Crit. Care Med. (2003) [Pubmed]
  2. Sequence analysis of HSPA1A and HSPA1B in a multi-ethnic study population. Smith, R.S., Meyers, D.A., Peters, S.P., Moore, W.C., Wenzel, S.A., Bleecker, E.R., Hawkins, G.A. DNA Seq. (2007) [Pubmed]
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