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Gene Review

HSPA1L  -  heat shock 70kDa protein 1-like

Homo sapiens

Synonyms: HSP70-1L, HSP70-HOM, HSP70-Hom, HSP70T, Heat shock 70 kDa protein 1-Hom, ...
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Disease relevance of HSPA1L


High impact information on HSPA1L

  • Phylogenetic analysis reveals that gene conversion has homogenized the entire coding regions of HSPA1A/B and several fragments of HSPA1L [6].
  • Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury [1].
  • Allele frequency of the HSPA1B 1538 G allele was 0.569, and that of the HSPA1L 2437 T allele was 0.821 [1].
  • An approximately 220-kb segment of DNA in the class III region separating the Hsp70 (HSPA1L) and BAT1 (D6S8IE) genes, which was previously known to contain 14 genes, has been analyzed for the presence of additional genes [7].
  • Susceptibility to abacavir hypersensitivity (ABC HSR) is strongly associated with alleles carried on the 57.1 ancestral haplotype including HLA-B*5701 and Hsp70 Hom M493T [8].

Biological context of HSPA1L


Other interactions of HSPA1L

  • Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia [10].
  • The two HSP70-Hom alleles were shown to be strongly associated to some specific HLA-B/DR haplotypes in random Finnish population and the segregation of the alleles as a part of these haplotypes was confirmed in 18 families [14].
  • In addition, the HSP70-Hom alleles of 31 patients with ankylosing spondylitis (AS) and 38 with reactive arthritis (ReA) were compared with each other and with 56 unrelated healthy HLA-B27 positive individuals [14].
  • The HSP70-Hom status was investigated also in 28 homozygous HLA typing cells and when compared with previously published results of HSP70-l and HSP70-2 polymorphisms, it appeared that these three MHC Class-III linked HSP70 genes segregated in fixed allelic combinations [14].
  • By typing 257 individuals from 55 IDDM multiple-case families two extended MHC-haplotypes, including class II-, TNF- and class I-markers, carrying the rare HSP70-Hom allele were defined [15].

Analytical, diagnostic and therapeutic context of HSPA1L


  1. Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury. Schröder, O., Schulte, K.M., Ostermann, P., Röher, H.D., Ekkernkamp, A., Laun, R.A. Crit. Care Med. (2003) [Pubmed]
  2. Is preeclampsia associated with higher frequency of HSP70 gene polymorphisms? Fekete, A., Vér, A., Bögi, K., Treszl, A., Rigó, J. Eur. J. Obstet. Gynecol. Reprod. Biol. (2006) [Pubmed]
  3. Polymorphisms of heat shock protein-70 (HSPA1B and HSPA1L loci) do not influence infection or outcome risk in critically ill surgical patients. Bowers, D.J., Calvano, J.E., Alvarez, S.M., Coyle, S.M., Macor, M.A., Kumar, A., Calvano, S.E., Lowry, S.F. Shock (2006) [Pubmed]
  4. Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant. Martin, A.M., Nolan, D., Gaudieri, S., Almeida, C.A., Nolan, R., James, I., Carvalho, F., Phillips, E., Christiansen, F.T., Purcell, A.W., McCluskey, J., Mallal, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Analysis of two human leukocyte antigen-linked polymorphic heat shock protein 70 genes in patients with severe sepsis. Schroeder, S., Reck, M., Hoeft, A., Stüber, F. Crit. Care Med. (1999) [Pubmed]
  6. Gene conversion and GC-content evolution in mammalian Hsp70. Kudla, G., Helwak, A., Lipinski, L. Mol. Biol. Evol. (2004) [Pubmed]
  7. Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B). Albertella, M.R., Jones, H., Thomson, W., Olavesen, M.G., Campbell, R.D. Genomics (1996) [Pubmed]
  8. HLA-B*5701 typing by sequence-specific amplification: validation and comparison with sequence-based typing. Martin, A.M., Nolan, D., Mallal, S. Tissue Antigens (2005) [Pubmed]
  9. Genomic structure of the spermatid-specific hsp70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man. Ito, Y., Ando, A., Ando, H., Ando, J., Saijoh, Y., Inoko, H., Fujimoto, H. J. Biochem. (1998) [Pubmed]
  10. Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia. Pae, C.U., Kim, T.S., Kwon, O.J., Artioli, P., Serretti, A., Lee, C.U., Lee, S.J., Lee, C., Paik, I.H., Kim, J.J. Neurosci. Res. (2005) [Pubmed]
  11. Structure and expression of the three MHC-linked HSP70 genes. Milner, C.M., Campbell, R.D. Immunogenetics (1990) [Pubmed]
  12. Characterization and regulation of the major histocompatibility complex-encoded proteins Hsp70-Hom and Hsp70-1/2. Fourie, A.M., Peterson, P.A., Yang, Y. Cell Stress Chaperones (2001) [Pubmed]
  13. Analysis of hsp70 gene polymorphism in allergic asthma. Aron, Y., Busson, M., Polla, B.S., Dusser, D., Lockhart, A., Swierczewski, E., Favatier, F. Allergy (1999) [Pubmed]
  14. HSP70-Hom NcoI polymorphism and HLA-associations in the Finnish population and in patients with ankylosing spondylitis or reactive arthritis. Westman, P., Partanen, J., Leirisalo-Repo, M., Koskimies, S. Eur. J. Immunogenet. (1994) [Pubmed]
  15. Polymorphic analysis of the human MHC-linked heat shock protein 70 (HSP70-2) and HSP70-Hom genes in insulin-dependent diabetes mellitus (IDDM). Pociot, F., Rønningen, K.S., Nerup, J. Scand. J. Immunol. (1993) [Pubmed]
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