High impact information on unc

• Extracellular recordings from mutant mechanosensory bristles revealed that mechanoreceptor potentials were absent or reduced in both unc and uncl mutants [1].
• Molecular and genetic studies on the euchromatin-heterochromatin transition region of the X chromosome of Drosophila melanogaster. 1. A cloned entry point near to the uncoordinated (unc) locus [2].
• UNCL, the human homolog of unc and uncl, is preferentially expressed in periodontal ligament (PDL) fibroblasts compared with gingival fibroblasts [3].
• Analyses of RNAs derived from genotypes that are deficient for the uncoordinated complementation group and from seven uncoordinated mutant alleles support the suggestion that the uncoordinated gene (unc) has been isolated and encodes the multiple transcripts [4].
• In the nematode Caenorhabditis elegans, a disruption of any of these steps causes uncoordinated locomotory behavior (unc phenotype) [5].

Biological context of unc

• A second genetic screen, for unc-like uncoordination, yielded mutations in seven genes on the second chromosome; mutations in five of these genes also reduced or eliminated bristle mechanoreceptor potentials [1].

Analytical, diagnostic and therapeutic context of unc

• We used electron microscopy of serial sections to reconstruct the ventral nerve-cords of uncoordinated (unc) mutants that have distinctive locomotory choreographies [6].

References