Disease relevance of dnaK

• In order to enhance the quantity and the protective properties of the antibodies induced by DNA vaccination with the heat shock protein dnaK gene of Chlamydophila abortus AB7 as well as to elicit an efficient cellular immune response, we vaccinated mice with a DNA prime followed by a boost with the recombinant DnaK protein [1].
• No delayed-type hypersensitivity reaction was observed and the spleens of dnaK vaccinated-mice were not protected against C. abortus challenge [2].

High impact information on dnaK

• Proteic boost enhances humoral response induced by DNA vaccination with the dnaK gene of Chlamydophila abortus but fails to protect pregnant mice against a virulence challenge [1].
• Nevertheless, spleens of dnaK vaccinated-pregnant mice were not protected [2].
• Protection evaluation against Chlamydophila abortus challenge by DNA vaccination with a dnaK-encoding plasmid in pregnant and non-pregnant mice [2].

Biological context of dnaK

• Mice were intramuscularly immunized with a dnaK-encoding DNA plasmid [2].

References